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413  Articles
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Akt1 is known to promote non-homologous end-joining (NHEJ)-mediated DNA double-strand break (DSB) repair by stimulation of DNA-PKcs. In the present study, we investigated the effect of Akt1 on homologous recombination (HR)-dependent repair of radiation-in... see more

Breast cancer is a heterogeneous disease that can be treated by surgery, systemic therapy, and radiotherapy. Adjuvant breast cancer radiotherapy has important implications for patient survival but also causes adverse events. During radiation, not only can... see more

The accurate repair of DNA is critical for genome stability and cancer prevention. DNA double-strand breaks are one of the most toxic lesions; however, they can be repaired using homologous recombination. Homologous recombination is a high-fidelity DNA re... see more

Genomic integrity is of outmost importance for the survival at the cellular and the organismal level and key to human health. To ensure the integrity of their DNA, cells have evolved maintenance programs collectively known as the DNA damage response. Part... see more

The DNA damage response (DDR) is a designation for a number of pathways that protects our DNA from various damaging agents. In normal cells, the DDR is extremely important for maintaining genome integrity, but in cancer cells these mechanisms counteract t... see more

Background: Zymomonas mobilis is a Gram-negative microaerophilic bacterium with excellent ethanol-producing capabilities. The RecET recombination system provides an efficient tool for direct targeting of genes in the bacterial chromosome by PCR fragments.... see more

Homologous recombination (HR) or illegitimate recombination (also known as non-homologous end-joining, NHEJ) are essential for the repair of DNA double strand breaks and cell survival. HR is also an essential part of meiosis, ensuring that new genetic com... see more

Pollution of the biosphere with heavy metals has phenomenally increased since the commencement of industrial revolution. It poses several environment and health concerns. High regeneration and metal accumulation capacity the possibility of genetic transfo... see more

Embryonic stem (ES) cells, the undifferentiated cells of early embryos are established as permanent lines and are characterised by their self-renewal capacity and the ability to retain their developmental capacity in vivo and in vitro. The pluripotent pro... see more

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