Cancers  

Sonia Leon-Cabrera, Armando Vázquez-Sandoval, Emmanuel Molina-Guzman, Yael Delgado-Ramirez, Norma L. Delgado-Buenrostro, Blanca E. Callejas, Yolanda I. Chirino, Carlos Pérez-Plasencia, Miriam Rodríguez-Sosa, Jonadab E. Olguín, Citlaltepetl Salinas, Abhay R. Satoskar and Luis I. Terrazas

Signal transducer and activator of transcription 1 (STAT1) is part of the Janus kinase (JAK/STAT) signaling pathway that controls critical events in intestinal immune function related to innate and adaptive immunity. Recent studies have implicated STAT1 i... see more

Beatrice U. Mueller, Katja Seipel, Ulrike Bacher and Thomas Pabst

While the majority of patients with acute myeloid leukemia (AML) are above the age of 65 years at diagnosis, the outcome of older AML patients remains disappointing. Even if standard intensive chemotherapy induces morphologic complete remission (CR1), rel... see more

Teresa Poggio, Justus Duyster and Anna L. Illert

T cell non-Hodgkin lymphoma (T-NHL) is a rare and heterogeneous group of neoplasms of the lymphoid system. With the exception of a few relatively indolent entities, T-NHL is typically aggressive, treatment resistant, and associated with poor prognosis. Re... see more

Tatsuya Ohno, Shin-ei Noda, Kazutoshi Murata, Yuya Yoshimoto, Noriyuki Okonogi, Ken Ando, Tomoaki Tamaki, Shingo Kato, Takashi Hirakawa, Tatsuya Kanuma, Takashi Minegishi, Takashi Nakano and On behalf of the Working Group for Gynecologic Cancer

A phase I study was performed to determine the recommended dose of carbon ion radiotherapy and 3D image-guided brachytherapy for histologically confirmed stage II (=4 cm), III, or IVA cervical cancer. Dose-limiting toxicities (treatment-related toxicities... see more

Amruta P. Nayak, Arvinder Kapur, Lisa Barroilhet and Manish S. Patankar

Aerobic glycolysis is an important metabolic adaptation of cancer cells. There is growing evidence that oxidative phosphorylation is also an active metabolic pathway in many tumors, including in high grade serous ovarian cancer. Metastasized ovarian tumor... see more

Brigitte Bauvois and Santos A. Susin

Human neutrophil gelatinase-associated lipocalin (NGAL) is a glycoprotein present in a wide variety of tissues and cell types. NGAL exists as a 25 kDa monomer, a 46 kDa homodimer (the most abundant form in healthy subjects) and a 130 kDa disulfide-linked ... see more

Aleksandra Simiczyjew, Ewelina Dratkiewicz, Marleen Van Troys, Christophe Ampe, Ilona Styczen and Dorota Nowak

Triple-negative breast cancer (TNBC) is the most challenging subtype to treat due to the lack of estrogen receptor, progesterone receptor, and HER2 expression, which excludes the usage of directed targeted therapy against them. Promising therapeutic targe... see more

Saúl Álvarez-Teijeiro, Cristina García-Inclán, M. Ángeles Villaronga, Pedro Casado, Francisco Hermida-Prado, Rocío Granda-Díaz, Juan P. Rodrigo, Fernando Calvo, Nagore Del-Río-Ibisate, Alberto Gandarillas, Francisco Morís, Mario Hermsen, Pedro Cutillas and Juana M. García-Pedrero

This study investigates for the first time the crosstalk between stromal fibroblasts and cancer stem cell (CSC) biology in head and neck squamous cell carcinomas (HNSCC), with the ultimate goal of identifying effective therapeutic targets. The effects of ... see more

Hiromasa Endo, Kanako Takayama, Kenji Mitsudo, Tatsuya Nakamura, Ichiro Seto, Hisashi Yamaguchi, Takashi Ono, Motohisa Suzuki, Yusuke Azami, Hitoshi Wada, Masao Murakami and Iwai Tohnai

This study aimed to evaluate the therapeutic effect and toxicity of proton beam therapy in combination with intra-arterial infusion chemotherapy in patients with squamous cell carcinoma of the maxillary gingiva. Between December 2010 and March 2016, 30 pa... see more

Ina Nepstad, Kimberley Joanne Hatfield, Tor Henrik Anderson Tvedt, Håkon Reikvam and Øystein Bruserud

Clonal heterogeneity detected by karyotyping is a biomarker associated with adverse prognosis in acute myeloid leukemia (AML). Constitutive activation of the phosphatidylinositol-3-kinase-Akt-mechanistic target of rapamycin (PI3K-Akt-mTOR) pathway is pres... see more

Isaac Jardin, Raquel Diez-Bello, Jose J. Lopez, Pedro C. Redondo, Ginés M. Salido, Tarik Smani and Juan A. Rosado

Transient receptor potential channels convey signaling information from a number of stimuli to a wide variety of cellular functions, mainly by inducing changes in cytosolic Ca2+ concentration. Different members of the TRPC, TRPM and TRPV subfamilies have ... see more

Jin Wang, Tianfang Wang, Yanfang Sun, Yuan Feng, William C. Kisseberth, Carolyn J. Henry, Irene Mok, Susan E. Lana, Kevin Dobbin, Nicole Northrup, Elizabeth W. Howerth and Shaying Zhao

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Gian Marco Elisi, Matteo Santucci, Domenico D’Arca, Angela Lauriola, Gaetano Marverti, Lorena Losi, Laura Scalvini, Maria Laura Bolognesi, Marco Mor and Maria Paola Costi

Drug repurposing is a fast and consolidated approach for the research of new active compounds bypassing the long streamline of the drug discovery process. Several drugs in clinical practice have been reported for modulating the major Hippo pathway’s... see more

Sameer Abdallah Dhayat, Max Michael Traeger, Jan Rehkaemper, Anda Jana Stroese, Konrad Steinestel, Eva Wardelmann, Iyad Kabar and Norbert Senninger

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive carcinoma entities worldwide with early and rapid dissemination. Recently, we discussed the role of microRNAs as epigenetic regulators of Epithelial-to-Mesenchymal Transition (EMT) in P... see more

Loukik Arora, Alan Prem Kumar, Frank Arfuso, Wee Joo Chng and Gautam Sethi

Signal transducer and activator of transcription 3 (STAT3), a member of the STAT protein family, can be phosphorylated by receptor-associated Janus kinases (JAKs) in response to stimulation by cytokines and growth factors. It forms homo- or heterodimers t... see more

Marius Ilié, Mélanie Beaulande, Saima Ben Hadj, Emmanuel Chamorey, Renaud Schiappa, Elodie Long-Mira, Sandra Lassalle, Catherine Butori, Charlotte Cohen, Sylvie Leroy, Olivier Guérin, Jérôme Mouroux, Charles-Hugo Marquette, Jean-François Pomerol, Gilles Erb, Véronique Hofman and Paul Hofman

With underrepresentation of elderly patients with lung adenocarcinoma (LADC) in anti-PD-1/PD-L1 clinical trials, better understanding of the interplay of PD-L1 and tumor-associated immune cells (TAICs) could assist clinicians in stratifying these patients... see more

Elena Madrazo, David Ruano, Lorea Abad, Estefanía Alonso-Gómez, Carmen Sánchez-Valdepeñas, África González-Murillo, Manuel Ramírez and Javier Redondo-Muñoz

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. As ALL progresses, leukemic cells cross the endothelial barrier and infiltrate other tissues. Epigenetic enzymes represent novel therapeutic targets in hematological malignancies, and... see more

Jean-Paul Soulillou, Caner Süsal, Bernd Döhler and Gerhard Opelz

Because of a mutation of the gene allowing the synthesis of the Neu5Gc form of neuraminidic acid, humans lack the Neu5Gc present in other mammals and develop anti-Neu5Gc. However, humans can absorb dietary Neu5Gc and normal colon epithelium displays minut... see more

Robert Berahovich, Hua Zhou, Shirley Xu, Yuehua Wei, Jasper Guan, Jian Guan, Hizkia Harto, Shuxiang Fu, Kaihuai Yang, Shuying Zhu, Le Li, Lijun Wu and Vita Golubovskaya

The cell-surface protein B cell maturation antigen (BCMA, CD269) has emerged as a promising target for CAR-T cell therapy for multiple myeloma. In order to create a novel BCMA CAR, we generated a new BCMA monoclonal antibody, clone 4C8A. This antibody exh... see more

Hideya Yamazaki, Koji Masui, Gen Suzuki, Satoaki Nakamura, Daisuke Shimizu, Tatsuyuki Nishikawa, Haruumi Okabe, Ken Yoshida, Tadayuki Kotsuma, Eiichi Tanaka, Keisuke Otani, Yasuo Yoshioka and Kazuhiko Ogawa

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Bernhard Ralla, Jonas Busch, Anne Flörcken, Jörg Westermann, Zhongwei Zhao, Ergin Kilic, Sabine Weickmann, Monika Jung, Annika Fendler and Klaus Jung

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Chin-Chuan Chen, Chi-Yuan Chen, Shu-Huei Wang, Chau-Ting Yeh, Shih-Chi Su, Shir-Hwa Ueng, Wen-Yu Chuang, Chuen Hsueh and Tong-Hong Wang

DNA repair systems are abnormally active in most hepatocellular carcinoma (HCC) cells due to accumulated mutations, resulting in elevated DNA repair capacity and resistance to chemotherapy and radiotherapy. Thus, targeting DNA repair mechanisms is a commo... see more

Changhoon Song, Joo-Hyun Chung, Sung-Bum Kang, Duck-Woo Kim, Heung-Kwon Oh, Hye Seung Lee, Jin Won Kim, Keun-Wook Lee, Jee Hyun Kim and Jae-Sung Kim

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Poorna Anandavadivelan, Lena Martin, Therese Djärv, Asif Johar and Pernilla Lagergren

We aimed to clarify the influence of nutritional problems after surgery for oesophageal cancer on functional health related quality of life (HRQOL) and survival. A prospective nationwide cohort of oesophageal cancer patients operated 2001–2005 in Sw... see more

Kang-Hoon Lee, Hyoung-Min Park, Keun-Hong Son, Tae-Jin Shin and Je-Yoel Cho

Breast cancer (BC)/mammary gland carcinoma (MGC) is the most frequently diagnosed and leading cause of cancer-related mortality in both women and canines. To better understand both canine MGC and human BC-specific genes, we sequenced RNAs obtained from ei... see more

Maximilian Weniger, Kim C. Honselmann and Andrew S. Liss

Pancreatic ductal adenocarcinoma (PDAC) has an extraordinarily dense fibrotic stroma that impedes tumor perfusion and delivery of anticancer drugs. Since the extracellular matrix (ECM) comprises the bulk of the stroma, it is primarily responsible for the ... see more

Laura Gonzalez dos Anjos, Bruna Cristine De Almeida, Thais Gomes de Almeida, André Mourão Lavorato Rocha, Giovana De Nardo Maffazioli, Fernando Augusto Soares, Isabela Werneck da Cunha, Edmund Chada Baracat and Katia Candido Carvalho

Changes in microRNA (miRNA) expression may lead to cancer development and/or contribute to its progression; however, their role in uterine sarcomas is poorly understood. Uterine sarcomas (US) belong to a rare class of heterogeneous tumors, representing ab... see more

Hung-Chih Hsu, Nina Lapke, Shu-Jen Chen, Yen-Jung Lu, Ren-Shiang Jhou, Chien-Yuh Yeh, Wen-Sy Tsai, Hsin-Yuan Hung, Jason Chia-Hsun Hsieh, Tsai-Sheng Yang, Tan Kien Thiam and Jeng-Fu You

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Renuka Sriram, Jeremy Gordon, Celine Baligand, Fayyaz Ahamed, Justin Delos Santos, Hecong Qin, Robert A. Bok, Daniel B. Vigneron, John Kurhanewicz, Peder E. Z. Larson and Zhen J. Wang

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Frances L. Byrne, Stefan R. Hargett, Sujoy Lahiri, R. Jack Roy, Stuart S. Berr, Stephen H. Caldwell and Kyle L. Hoehn

Rodent models of liver tumorigenesis have reproducibly shown that dietary sugar intake is a powerful driver of liver tumor initiation and growth. In contrast, dietary sugar restriction with ketogenic diets or calorie restriction generally prevents liver t... see more