30 articles in this issue
Annkathrin Hanssen, Carlotta Riebensahm, Malte Mohme, Simon A. Joosse, Janna-Lisa Velthaus, Lars Arne Berger, Christian Bernreuther, Markus Glatzel, Sonja Loges, Katrin Lamszus, Manfred Westphal, Sabine Riethdorf, Klaus Pantel and Harriet Wikman
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Fiona H. Tan, Tracy L. Putoczki, Jieqiong Lou, Elizabeth Hinde, Frédéric Hollande, Julie Giraud, Stanley S. Stylli, Lucia Paradiso, Hong-Jian Zhu, Oliver M. Sieber and Rodney B. Luwor
Signal transducer and activator of transcription 3 (STAT3) signaling is a major driver of colorectal cancer (CRC) growth, however therapeutics, which can effectively target this pathway, have so far remained elusive. Here, we performed an extensive screen... see more
Alexander Ring, Cu Nguyen, Goar Smbatyan, Debu Tripathy, Min Yu, Michael Press, Michael Kahn and Julie E. Lang
Joanne Kotsopoulos
Yang Xin Zi Xu and Suresh Mishra
The worldwide prevalence of obesity has doubled during the last 50 years, and according to the World Obesity Federation, one third of the people on Earth will be obese by the year 2025. Obesity is described as a chronic, relapsing and multifactorial disea... see more
Irene Golán, Laura Rodríguez de la Fuente and Jose A. Costoya
Glioblastoma (GB) is the most aggressive and most common malignant primary brain tumor diagnosed in adults. GB shows a poor prognosis and, unfortunately, current therapies are unable to improve its clinical outcome, imposing the need for innovative therap... see more
Joaquin Manzo-Merino, Alfredo Lagunas-Martínez, Carla O. Contreras-Ochoa, Marcela Lizano, Leonardo J. Castro-Muñoz, Crysele Calderón-Corona, Kirvis Torres-Poveda, Alicia Román-Gonzalez, Rogelio Hernández-Pando, Margarita Bahena-Román and Vicente Madrid-Marina
Persistent infection with high-risk Human Papillomavirus (HR-HPV) is the main requisite for cervical cancer development. Normally, HPV is limited to the site of infection and regulates a plethora of cellular elements to avoid the immune surveillance by in... see more
Lu Qiu, Meng Wang, Shaofan Hu, Xufang Ru, Yonggang Ren, Zhengwen Zhang, Siwang Yu and Yiguo Zhang
Carolin Offenhäuser, Fares Al-Ejeh, Simon Puttick, Kathleen S. Ensbey, Zara C. Bruce, Paul R. Jamieson, Fiona M. Smith, Brett W. Stringer, Benjamin Carrington, Adrian V. Fuchs, Craig A. Bell, Rosalind Jeffree, Stephen Rose, Kristofer J. Thurecht, Andrew W. Boyd and Bryan W. Day
The EphA3 receptor has recently emerged as a functional tumour-specific therapeutic target in glioblastoma (GBM). EphA3 is significantly elevated in recurrent disease, is most highly expressed on glioma stem cells (GSCs), and has a functional role in main... see more
Joakim Crona, Samuel Backman, Staffan Welin, David Taïeb, Per Hellman, Peter Stålberg, Britt Skogseid and Karel Pacak
Adrenocortical carcinoma (ACC) and pheochromocytoma and paraganglioma (PPGL) are defined by clinicopathological criteria and can be further sub-divided based on different molecular features. Whether differences between these molecular subgroups are signif... see more
Claudia Mazo, Estibaliz Orue-Etxebarria, Ignacio Zabalza, Maria d. M. Vivanco, Robert M. Kypta and Andoni Beristain
Lujun Shen, Mian Xi, Lei Zhao, Xuhui Zhang, Xiuchen Wang, Zhimei Huang, Qifeng Chen, Tianqi Zhang, Jingxian Shen, Mengzhong Liu and Jinhua Huang
Shang-Jui Wang and Bruce Haffty
Recent development in radiation biology has revealed potent immunogenic properties of radiotherapy in cancer treatments. However, antitumor immune effects of radiotherapy are limited by the concomitant induction of radiation-dependent immunosuppressive ef... see more
Sumit Siddharth and Dipali Sharma
Triple negative breast cancer (TNBC) is a molecularly heterogeneous disease whose incidence is disproportionately higher in African American (AA) women compared to European American (EA) women. Earlier onset, more advanced stage at diagnosis, and aggressi... see more
Xiaowen Zhang and Rong Li
Jang-Chun Lin, Jo-Ting Tsai, Tsu-Yi Chao, Hsin-I Ma and Wei-Hsiu Liu
Glioblastoma multiforme (GBM) requires radiotherapy (RT) as a part of definitive management strategy. RT is highly effective, destroying cancer cells that may exist around the surgical tumor bed. However, GBM still has a poor prognosis and a high local re... see more
Viktor Hlavac, Maria Kovacova, Katerina Elsnerova, Veronika Brynychova, Renata Kozevnikovova, Karel Raus, Katerina Kopeckova, Sona Mestakova, David Vrana, Jiri Gatek, Pavel Ostasov, Radka Vaclavikova and Pavel Soucek
Rohit Gosain, Sarbajit Mukherjee, Sai S. Yendamuri and Renuka Iyer
Neuroendocrine tumors (NETs) are a group of malignancies that originated from neuroendocrine cells, with the most common sites being lungs and the gastrointestinal tract. Lung NETs comprise 25% of all lung malignancies. Small cell lung cancer is the most ... see more
Monica Ceccon, Mario Mauri, Luca Massimino, Giovanni Giudici, Rocco Piazza, Carlo Gambacorti-Passerini and Luca Mologni
Targeted therapy is an effective, rational, and safe approach to solid and hematological tumors treatment. Unfortunately, a significant fraction of patients treated with tyrosine kinase inhibitors (TKI) relapses mainly because of gene amplification, mutat... see more
Satoshi Shibata, Shigeyuki Takamatsu, Kazutaka Yamamoto, Miu Mizuhata, Sayuri Bou, Yoshitaka Sato, Mariko Kawamura, Satoko Asahi, Yuji Tameshige, Yoshikazu Maeda, Makoto Sasaki, Tomoyasu Kumano, Satoshi Kobayashi, Hiroyasu Tamamura and Toshifumi Gabata
The authors wish to make the following corrections to this paper [...]
Young Hwa Soung, Shane Ford, Cecilia Yan and Jun Chung
Emanuel Nicolas, François Bertucci, Renaud Sabatier and Anthony Gonçalves
Stephanie Pei Tung Yiu, Kwai Fung Hui, Chung King Choi, Richard Yi Tsun Kao, Chi Wang Ma, Dan Yang and Alan Kwok Shing Chiang
Pauline Roussille, Gaelle Tachon, Claire Villalva, Serge Milin, Eric Frouin, Julie Godet, Antoine Berger, Sheik Emambux, Christos Petropoulos, Michel Wager, Lucie Karayan-Tapon and David Tougeron
Daniel J. De Klerk, Richard J. Honeywell, Gerrit Jansen and Godefridus J. Peters
Tyrosine kinase inhibitors are a class of chemotherapeutic drugs that target specific protein kinases. These tyrosine kinase inhibitors constitute a relatively new class of drugs which target for instance Bcr-Abl, Epidermal Growth Factor Receptor (EGFR) a... see more
Marieke H. J. Van den Beuken-van Everdingen, Sander M. J. Van Kuijk, Daisy J. A. Janssen and Elbert A. J. Joosten
Despite increased attention to cancer pain, pain prevalence in patients with cancer has not improved over the last decade and one third of cancer patients on anticancer therapy and half of patients with advanced disease still suffer from moderate to sever... see more
Jen-Shi Chen, Chia-Yen Hung, Hung Chang, Chien-Ting Liu, Yen-Yang Chen, Chang-Hsien Lu, Pei-Hung Chang, Yu-Shin Hung and Wen-Chi Chou
Background: Few studies have reported the epidemiology and clinical outcome of venous thromboembolism (VTE) in Asian patients with pancreatic cancer. This study investigated the incidence, risk factors, and clinical outcome of VTE in patients with pancrea... see more
Marjolein J. A. Weerts, Marcel Smid, John A. Foekens, Stefan Sleijfer and John W. M. Martens
The human mitochondrial DNA (mtDNA) encodes 37 genes, including thirteen proteins essential for the respiratory chain, and RNAs functioning in the mitochondrial translation apparatus. The total number of mtDNA molecules per cell (mtDNA content) is variabl... see more
Tasleem Arif, Avijit Paul, Yakov Krelin, Anna Shteinfer-Kuzmine and Varda Shoshan-Barmatz
Oncogenic properties, along with the metabolic reprogramming necessary for tumour growth and motility, are acquired by cancer cells. Thus, tumour metabolism is becoming a target for cancer therapy. Here, cancer cell metabolism was tackled by silencing the... see more
Guilan Shi, Chelsea Edelblute, Sezgi Arpag, Cathryn Lundberg and Richard Heller
Metastatic melanoma is an aggressive skin cancer with a relatively low survival rate. Immune-based therapies have shown promise in the treatment of melanoma, but overall complete response rates are still low. Previous studies have demonstrated the potenti... see more