30 articles in this issue
Chun-Ho Chu, Shih-Ching Chang, Hsiu-Hua Wang, Shung-Haur Yang, Kuo-Chu Lai and Te-Chang Lee
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Lei Qin, Tsung-Ming Chen, Yi-Wei Kao, Kuan-Chou Lin, Kevin Sheng-Po Yuan, Alexander T. H. Wu, Ben-Chang Shia and Szu-Yuan Wu
Elena Mariotto, Giampietro Viola, Roberto Ronca, Luca Persano, Sanja Aveic, Zaver M. Bhujwalla, Noriko Mori, Benedetta Accordi, Valentina Serafin, Luisa Carlota López-Cara and Roberta Bortolozzi
Choline kinase (ChoK) is the first enzyme of the Kennedy pathway leading to the biosynthesis of phosphatidylcholine (PtdCho), the most abundant phospholipid in eukaryotic cell membranes. EB-3D is a novel choline kinase α1 (ChoKα1) inhibitor wi... see more
Flora Nguyen Van Long, Audrey Lardy-Cleaud, Susan Bray, Sylvie Chabaud, Thierry Dubois, Alexandra Diot, Lee B. Jordan, Alastair M. Thompson, Jean-Christophe Bourdon, David Perol, Philippe Bouvet, Jean-Jacques Diaz and Virginie Marcel
Markus Bo Schoenberg, Jingcheng Hao, Julian Nikolaus Bucher, Rainer Christoph Miksch, Hubertus Johann Wolfgang Anger, Barbara Mayer, Julia Mayerle, Jens Neumann, Markus Otto Guba, Jens Werner and Alexandr V. Bazhin
Sati Akbaba, Kristin Lang, Thomas Held, Olcay Cem Bulut, Matthias Mattke, Matthias Uhl, Alexandra Jensen, Peter Plinkert, Stefan Rieken, Klaus Herfarth, Juergen Debus and Sebastian Adeberg
Nikolai Siebert, Sascha Troschke-Meurer, Madlen Marx, Maxi Zumpe, Karoline Ehlert, Juliet Gray, Alberto Garaventa, Carla Manzitti, Shifra Ash, Thomas Klingebiel, James Beck, Victoria Castel, Dominique Valteau-Couanet, Hans Loibner, Ruth Ladenstein and Holger N. Lode
GD2-directed immunotherapies improve survival of high-risk neuroblastoma (NB) patients (pts). Treatment with chimeric anti-GD2 antibodies (Ab), such as ch14.18, can induce development of human anti-chimeric Ab (HACA). Here, we report HACA effects on ch14.... see more
Hiroshi Sugano, Yoshihiro Shirai, Takashi Horiuchi, Nobuhiro Saito, Yohta Shimada, Ken Eto, Tadashi Uwagawa, Toya Ohashi and Katsuhiko Yanaga
Neoadjuvant chemoradiotherapy followed by radical surgery is the standard treatment for patients with locally advanced low rectal cancer. However, several studies have reported that ionizing radiation (IR) activates nuclear factor kappa B (NF-κB) th... see more
Christine Naczki, Bincy John, Chirayu Patel, Ashlyn Lafferty, Alia Ghoneum, Hesham Afify, Michael White, Amanda Davis, Guangxu Jin, Steven Kridel and Neveen Said
Ashley M. Hopkins, Anh-Minh Nguyen, Christos S. Karapetis, Andrew Rowland and Michael J. Sorich
Yutaka Hata
Eunice L. Lozada-Delgado, Nilmary Grafals-Ruiz, Miguel A. Miranda-Román, Yasmarie Santana-Rivera, Fatma Valiyeva, Mónica Rivera-Díaz, María J. Marcos-Martínez and Pablo E. Vivas-Mejía
Glioblastoma (GBM) is the most common and aggressive of all brain tumors, with a median survival of only 14 months after initial diagnosis. Novel therapeutic approaches are an unmet need for GBM treatment. MicroRNAs (miRNAs) are a class of small non-codin... see more
Francisca Dias, Mariana Morais, Ana Luísa Teixeira and Rui Medeiros
Esophageal cancer (EC) is the eighth most common and sixth leading cause of cancer-related mortality in the world. Despite breakthroughs in EC diagnosis and treatment, patients with complete pathologic response after being submitted to chemoradiotherapy a... see more
Norbaini Binti Abdol Razak, Gabrielle Jones, Mayank Bhandari, Michael C. Berndt and Pat Metharom
Cancer-associated thrombosis is a major cause of mortality in cancer patients, the most common type being venous thromboembolism (VTE). Several risk factors for developing VTE also coexist with cancer patients, such as chemotherapy and immobilisation, con... see more
Nitya V. Sharma, Kathryn L. Pellegrini, Veronique Ouellet, Felipe O. Giuste, Selvi Ramalingam, Kenneth Watanabe, Eloise Adam-Granger, Lucresse Fossouo, Sungyong You, Michael R. Freeman, Paula Vertino, Karen Conneely, Adeboye O. Osunkoya, Dominique Trudel, Anne-Marie Mes-Masson, John A. Petros, Fred Saad and Carlos S. Moreno
Background: Patients with locally advanced or recurrent prostate cancer typically undergo androgen deprivation therapy (ADT), but the benefits are often short-lived and the responses variable. ADT failure results in castration-resistant prostate cancer (C... see more
Jinbin Chen, Kangqiang Peng, Dandan Hu, Jingxian Shen, Zhongguo Zhou, Li Xu, Jiancong Chen, Yangxun Pan, Juncheng Wang, Yaojun Zhang and Minshan Chen
Sanne De Wit, Leonie L. Zeune, T. Jeroen N. Hiltermann, Harry J. M. Groen, Guus Van Dalum and Leon W. M. M. Terstappen
Sandra López-Verdín, Jesús Lavalle-Carrasco, Ramón G. Carreón-Burciaga, Nicolás Serafín-Higuera, Nelly Molina-Frechero, Rogelio González-González and Ronell Bologna-Molina
This manuscript provides an update to the literature on molecules with roles in tumor resistance therapy in head and neck squamous cell carcinoma (HNSCC). Although significant improvements have been made in the treatment for head and neck squamous cell ca... see more
Henry D. McCann, Charlotte E. Johnson, Rachel J. Errington, D. Mark Davies, Elaine A. Dunlop and Andrew R. Tee
To find new anti-cancer drug therapies, we wanted to exploit homeostatic vulnerabilities within Tuberous Sclerosis Complex 2 (TSC2)-deficient cells with mechanistic target of rapamycin complex 1 (mTORC1) hyperactivity. We show that nelfinavir and mefloqui... see more
Yu-Jen Liu, Ngan-Ming Tsang, Chuen Hsueh, Chi-Ju Yeh, Shir-Hwa Ueng, Tong-Hong Wang and Wen-Yu Chuang
Arnatchai Maiuthed, Chuanpit Ninsontia, Katharina Erlenbach-Wuensch, Benardina Ndreshkjana, Julienne K. Muenzner, Aylin Caliskan, Husayn Ahmed P., Chatchai Chaotham, Arndt Hartmann, Adriana Vial Roehe, Vijayalakshmi Mahadevan, Pithi Chanvorachote and Regine Schneider-Stock
The oncogenic cytoplasmic p21 contributes to cancer aggressiveness and chemotherapeutic failure. However, the molecular mechanisms remain obscure. Here, we show for the first time that cytoplasmic p21 mediates 5-Fluorouracil (5FU) resistance by shuttling ... see more
Johanna Buchroithner, Friedrich Erhart, Josef Pichler, Georg Widhalm, Matthias Preusser, Günther Stockhammer, Martha Nowosielski, Sarah Iglseder, Christian F. Freyschlag, Stefan Oberndorfer, Karin Bordihn, Gord Von Campe, Markus Hoffermann, Reinhard Ruckser, Karl Rössler, Sabine Spiegl-Kreinecker, Michael B. Fischer, Thomas Czech, Carmen Visus, Günther Krumpl, Thomas Felzmann and Christine Marosi
Gaetano Verde, Lara I. De Llobet, Roni H.G. Wright, Javier Quilez, Sandra Peiró, François Le Dily and Miguel Beato
Mariantonia Logozzi, Davide Mizzoni, Daniela F. Angelini, Rossella Di Raimo, Mario Falchi, Luca Battistini and Stefano Fais
Exosomes are extracellular nanovesicles primarily involved in the pathogenesis of many diseases including cancer. This study was set out from recent evidence that extracellular acidity may increase the exosome release by cancer cells. However, this prelim... see more
Madhawa Neranjan Gunathilake, Jeonghee Lee, Aelee Jang, Il Ju Choi, Young-Il Kim and Jeongseon Kim
Sanjeevani Arora, Joshua R. Heyza, Elaine C. Chalfin, Randall J. Ruch and Steve M. Patrick
Naoshi Nishida, Takafumi Nishimura, Toshimi Kaido, Kosuke Minaga, Kentaro Yamao, Ken Kamata, Mamoru Takenaka, Hiroshi Ida, Satoru Hagiwara, Yasunori Minami, Toshiharu Sakurai, Tomohiro Watanabe and Masatoshi Kudo
Vijayalaxmi Gupta, Fiona Yull and Dineo Khabele
Ovarian cancer, a rare but fatal disease, has been a challenging area in the field of gynecological cancer. Ovarian cancer is characterized by peritoneal metastasis, which is facilitated by a cross-talk between tumor cells and other cells in the tumor mic... see more
Maxim Sorokin, Roman Kholodenko, Maria Suntsova, Galina Malakhova, Andrew Garazha, Irina Kholodenko, Elena Poddubskaya, Dmitriy Lantsov, Ivan Stilidi, Petr Arhiri, Andreyan Osipov and Anton Buzdin
Sequential courses of anticancer target therapy lead to selection of drug-resistant cells, which results in continuous decrease of clinical response. Here we present a new approach for predicting effective combinations of target drugs, which act in a syne... see more
Yusuke Matsuno, Mai Hyodo, Haruka Fujimori, Atsuhiro Shimizu and Ken-ichi Yoshioka
Radiation and certain anticancer drugs damage DNA, resulting in apoptosis induction in cancer cells. Currently, the major limitations on the efficacy of such therapies are development of resistance and adverse side effects. Sensitization is an important s... see more