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18.248  Articles
1 of 1.826 pages  |  10  records  |  more records»
Calix[4]arene are known to be a promising scaffold for designing inhibitors of protein tyrosine phosphatases.In this work calix[4]arene mono- and bis-a-hydroxymethylphosphonic acids have been tested in vitro for the inhibitory activity against some therap... see more

A new scoring function H1 recently developed for molecular docking has been tested on the complexes of protein tyrosine phosphatase 1B (PTP1B) from the PDB data bank and using docking of a set of inhibitors from the NIH database. The function is... see more

The protein tyrosine phosphatase (PTP) family is involved in multiple cellular functions and plays an important role in various pathological and physiological processes. In many chronic diseases, for example cancer, PTP is a potential therapeutic target f... see more

Previously, phosphonic acid derivatives of calix[4]arene and thiacalix[4]arene were found to be potential inhibitors of protein tyrosine phosphatase 1B. In the present paper, the inhibitory activity of unsubstituted sulfonyl-bridget calix[4]arene towards ... see more

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Protein tyrosine kinases form an important target for a new class of anticancer drugs, the tyrosine kinase inhibitors (TKIs). Recently we demonstrated that sunitinib, an inhibitor of the membrane-associated vascular endothelial growth factor receptor (VEG... see more

The protein tyrosine phosphatase interacting protein 51 (PTPIP51) regulates and interconnects signaling pathways, such as the mitogen-activated protein kinase (MAPK) pathway and an abundance of different others, e.g., Akt signaling, NF-κB signaling,... see more

Tyrosine kinase inhibitors are a class of chemotherapeutic drugs that target specific protein kinases. These tyrosine kinase inhibitors constitute a relatively new class of drugs which target for instance Bcr-Abl, Epidermal Growth Factor Receptor (EGFR) a... see more

Many potentially valuable drugs, including protein kinase inhibitors (PKI), risk being dropped from further development, without exploration of their clinical benefits, if early studies show these drugs to inhibit hERG channel and therefore, to have a pot... see more

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