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6  Articles
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A new scoring function H1 recently developed for molecular docking has been tested on the complexes of protein tyrosine phosphatase 1B (PTP1B) from the PDB data bank and using docking of a set of inhibitors from the NIH database. The function is... see more

Previously, phosphonic acid derivatives of calix[4]arene and thiacalix[4]arene were found to be potential inhibitors of protein tyrosine phosphatase 1B. In the present paper, the inhibitory activity of unsubstituted sulfonyl-bridget calix[4]arene towards ... see more

           Diabetes mellitus tipe 2 disebabkan oleh ekspresi PTP1B yang tinggi dan  mempengaruhi aktivitas PTKs, yang menyebabkan insulin gagal berikatan dengan reseptor insulin dan menginduksi resistensi insulin. Senyaw... see more

Calix[4]arene are known to be a promising scaffold for designing inhibitors of protein tyrosine phosphatases.In this work calix[4]arene mono- and bis-a-hydroxymethylphosphonic acids have been tested in vitro for the inhibitory activity against some therap... see more

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