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ISSN: 1422-0067    frecuency : 4   format : Electrónica

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Volume 20 Number 1 Part January-1 Year 2019

30 articles in this issue 

Rita Moretti and Paola Caruso

Homocysteine (Hcy) is a sulfur-containing amino acid that is generated during methionine metabolism. Physiologic Hcy levels are determined primarily by dietary intake and vitamin status. Elevated plasma levels of Hcy can be caused by deficiency of either ... see more

 

Edith Emmings, Sally Mullany, Zenas Chang, Charles N. Landen, Jr., Stig Linder and Martina Bazzaro

Ovarian cancer is the leading cause of death from gynecologic malignancy in the Western world. This is due, in part, to the fact that despite standard treatment of surgery and platinum/paclitaxel most patients recur with ultimately chemoresistant disease.... see more

 

Christina Rautenberg, Ulrich Germing, Rainer Haas, Guido Kobbe and Thomas Schroeder

Acute myeloid leukemia (AML) is a phenotypically and prognostically heterogeneous hematopoietic stem cell disease that may be cured in eligible patients with intensive chemotherapy and/or allogeneic stem cell transplantation (allo-SCT). Tremendous advance... see more

 

Bastian Schirmer, Klaudia Giehl and Katharina F. Kubatzky

The annual meeting “Signal Transduction—Receptors, Mediators, and Genes” of the Signal Transduction Society (STS) is an interdisciplinary conference open to all scientists sharing the common interest in elucidating signaling pathways in ... see more

 

Lianhua Piao, Zhou Chen, Qiuye Li, Ranran Liu, Wei Song, Ren Kong and Shan Chang

Specific interactions between scaffold protein SH3 and multiple ankyrin repeat domains protein 3 (Shank3) and synapse-associated protein 90/postsynaptic density-95–associated protein (SAPAP) are essential for excitatory synapse development and plast... see more

 

Austin K. Mircheff, Yanru Wang, Billy X. Pan, Leili Parsa, Prachi Nandoskar and Chuanqing Ding

Understanding the formation of Sjogren’s lymphocytic infiltrates could permit earlier diagnosis and better outcomes. We submitted gene transcript abundances in histologically normal rabbit lacrimal glands to principal component analysis. The analysi... see more

 

Sandesh D. Reddy, Iyan Younus, Vidya Sridhar and Doodipala Samba Reddy

This article provides an overview of neuroimaging biomarkers in experimental epileptogenesis and refractory epilepsy. Neuroimaging represents a gold standard and clinically translatable technique to identify neuropathological changes in epileptogenesis an... see more

 

Yulia Michailov, Eitan Lunenfeld, Joseph Kapilushnik, Shevach Friedler, Eckart Meese and Mahmoud Huleihel

Leukemia is one of the most common cancers in patients of reproductive age. It is well known that chemotherapy, used as anti-cancer therapy, adversely affects male fertility. Moreover, the negative effect of leukemia on sperm quality, even before chemothe... see more

 

Darius Häusler and Martin S. Weber

The exact cause of multiple sclerosis (MS) remains elusive. Various factors, however, have been identified that increase an individual’s risk of developing this central nervous system (CNS) demyelinating disease and are associated with an accelerati... see more

 

Hideyuki Kawauchi, Kazuhiko Yanai, De-Yun Wang, Koju Itahashi and Kimihiro Okubo

Antihistamines targeting the histamine H1 receptor play an important role in improving and maintaining the quality of life of patients with allergic rhinitis. For more effective and safer use of second-generation drugs, which are recommended by various gu... see more

 

Jing Zhao, Bo Qin, Rainer Nikolay, Christian M. T. Spahn and Gong Zhang

In all kingdoms of life, proteins are synthesized by ribosomes in a process referred to as translation. The amplitude of translational regulation exceeds the sum of transcription, mRNA degradation and protein degradation. Therefore, it is essential to inv... see more

 

Rolf Teschke

The current Special Issue is devoted to the broad spectrum of hepatotoxicity with its molecular mechanisms and pathophysiology, presented in eight publications [...]

 

Janusz Blasiak, Elzbieta Pawlowska, Joanna Szczepanska and Kai Kaarniranta

Age-related macular degeneration (AMD) is a complex eye disease with many pathogenesis factors, including defective cellular waste management in retinal pigment epithelium (RPE). Main cellular waste in AMD are: all-trans retinal, drusen and lipofuscin, co... see more

 

Tuo Qi, Jia Guo, Huan Peng, Peng Liu, Zhensheng Kang and Jun Guo

Wheat and barley are the most highly produced and consumed grains in the world. Various pathogens—viruses, bacteria, fungi, insect pests, and nematode parasites—are major threats to yield and economic losses. Strategies for the management of d... see more

 

Julia Thom Oxford, Jonathon C. Reeck and Makenna J. Hardy

The evolution of multicellular metazoan organisms was marked by the inclusion of an extracellular matrix (ECM), a multicomponent, proteinaceous network between cells that contributes to the spatial arrangement of cells and the resulting tissue organizatio... see more

 

Giuseppe Cappellano, Cristoforo Comi, Annalisa Chiocchetti and Umberto Dianzani

Tolerogenic vaccines are aimed at inhibiting antigen-specific immune responses. Antigen-loaded nanoparticles (NPs) have been recently emerged as ideal tools for tolerogenic vaccination because their composition, size, and capability of loading immunomodul... see more