30 articles in this issue
International Journal of Molecular Sciences Editorial Office
Rigorous peer-review is the corner-stone of high-quality academic publishing [...]
Rita Moretti and Paola Caruso
Homocysteine (Hcy) is a sulfur-containing amino acid that is generated during methionine metabolism. Physiologic Hcy levels are determined primarily by dietary intake and vitamin status. Elevated plasma levels of Hcy can be caused by deficiency of either ... see more
Guillaume Poiroux, Annick Barre, Mathias Simplicien, Sandrine Pelofy, Bruno Segui, Els J. M. Van Damme, Pierre Rougé and Hervé Benoist
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Edith Emmings, Sally Mullany, Zenas Chang, Charles N. Landen, Jr., Stig Linder and Martina Bazzaro
Ovarian cancer is the leading cause of death from gynecologic malignancy in the Western world. This is due, in part, to the fact that despite standard treatment of surgery and platinum/paclitaxel most patients recur with ultimately chemoresistant disease.... see more
Christina Rautenberg, Ulrich Germing, Rainer Haas, Guido Kobbe and Thomas Schroeder
Acute myeloid leukemia (AML) is a phenotypically and prognostically heterogeneous hematopoietic stem cell disease that may be cured in eligible patients with intensive chemotherapy and/or allogeneic stem cell transplantation (allo-SCT). Tremendous advance... see more
Bastian Schirmer, Klaudia Giehl and Katharina F. Kubatzky
The annual meeting “Signal Transduction—Receptors, Mediators, and Genes” of the Signal Transduction Society (STS) is an interdisciplinary conference open to all scientists sharing the common interest in elucidating signaling pathways in ... see more
Hiroshi Yasuda, Masatoshi Nakagawa, Hirofumi Kiyokawa, Eisaku Yoshida, Toru Yoshimura, Naohiko Koshikawa, Fumio Itoh and Motoharu Seiki
Laminin (Ln)-332 consists of α3, β3, and γ2 chains, which mediate epithelial cell adhesion to the basement membrane. Ln-γ2, a component of Ln-332, is frequently expressed as a monomer in the invasion front of several types of malign... see more
John T. Lafin, Ehab H. Sarsour, Amanda L. Kalen, Brett A. Wagner, Garry R. Buettner and Prabhat C. Goswami
Lianhua Piao, Zhou Chen, Qiuye Li, Ranran Liu, Wei Song, Ren Kong and Shan Chang
Specific interactions between scaffold protein SH3 and multiple ankyrin repeat domains protein 3 (Shank3) and synapse-associated protein 90/postsynaptic density-95–associated protein (SAPAP) are essential for excitatory synapse development and plast... see more
Austin K. Mircheff, Yanru Wang, Billy X. Pan, Leili Parsa, Prachi Nandoskar and Chuanqing Ding
Understanding the formation of Sjogren’s lymphocytic infiltrates could permit earlier diagnosis and better outcomes. We submitted gene transcript abundances in histologically normal rabbit lacrimal glands to principal component analysis. The analysi... see more
Wenqi Li, Yulin Jia, Fengquan Liu, Fangquan Wang, Fangjun Fan, Jun Wang, Jinyan Zhu, Yang Xu, Weigong Zhong and Jie Yang
Li-Qin Li, Cheng-Cheng Lyu, Jia-Hao Li, Zhu Tong, Yi-Fei Lu, Xi-Yao Wang, Su Ni, Shi-Min Yang, Fu-Chun Zeng and Li-Ming Lu
Sandesh D. Reddy, Iyan Younus, Vidya Sridhar and Doodipala Samba Reddy
This article provides an overview of neuroimaging biomarkers in experimental epileptogenesis and refractory epilepsy. Neuroimaging represents a gold standard and clinically translatable technique to identify neuropathological changes in epileptogenesis an... see more
Yulia Michailov, Eitan Lunenfeld, Joseph Kapilushnik, Shevach Friedler, Eckart Meese and Mahmoud Huleihel
Leukemia is one of the most common cancers in patients of reproductive age. It is well known that chemotherapy, used as anti-cancer therapy, adversely affects male fertility. Moreover, the negative effect of leukemia on sperm quality, even before chemothe... see more
Darius Häusler and Martin S. Weber
The exact cause of multiple sclerosis (MS) remains elusive. Various factors, however, have been identified that increase an individual’s risk of developing this central nervous system (CNS) demyelinating disease and are associated with an accelerati... see more
Chao-Cheng Chen, Jia-Je Li, Nai-Hua Guo, Deng-Yuan Chang, Chung-Yih Wang, Jenn-Tzong Chen, Wuu-Jyh Lin, Kwan-Hwa Chi, Yi-Jang Lee, Ren-Shyan Liu, Chuan-Lin Chen and Hsin-Ell Wang
Colorectal cancer is one of the major causes of cancer-related death in Taiwan and worldwide. Patients with peritoneal metastasis from colorectal cancer have reduced overall survival and poor prognosis. Hybrid protein-inorganic nanoparticle systems have d... see more
Pallavi Jain, Pier-Luc Clermont, Francis Desmeules, Amina Zoubeidi, Bertrand Neveu and Frédéric Pouliot
Qi Xue, Xiao-Qin Wu, Wan-Jun Zhang, Li-Na Deng and Miao-Miao Wu
Haruka Nomoto, Akiyoshi Takami, J. Luis Espinoza, Makoto Onizuka, Koichi Kashiwase, Yasuo Morishima, Takahiro Fukuda, Yoshihisa Kodera, Noriko Doki, Koichi Miyamura, Takehiko Mori, Shinji Nakao and Eriko Morishita
Hideyuki Kawauchi, Kazuhiko Yanai, De-Yun Wang, Koju Itahashi and Kimihiro Okubo
Antihistamines targeting the histamine H1 receptor play an important role in improving and maintaining the quality of life of patients with allergic rhinitis. For more effective and safer use of second-generation drugs, which are recommended by various gu... see more
Jing Zhao, Bo Qin, Rainer Nikolay, Christian M. T. Spahn and Gong Zhang
In all kingdoms of life, proteins are synthesized by ribosomes in a process referred to as translation. The amplitude of translational regulation exceeds the sum of transcription, mRNA degradation and protein degradation. Therefore, it is essential to inv... see more
Rolf Teschke
The current Special Issue is devoted to the broad spectrum of hepatotoxicity with its molecular mechanisms and pathophysiology, presented in eight publications [...]
Janusz Blasiak, Elzbieta Pawlowska, Joanna Szczepanska and Kai Kaarniranta
Age-related macular degeneration (AMD) is a complex eye disease with many pathogenesis factors, including defective cellular waste management in retinal pigment epithelium (RPE). Main cellular waste in AMD are: all-trans retinal, drusen and lipofuscin, co... see more
Stefano Del Duca, Iris Aloisi, Luigi Parrotta and Giampiero Cai
Hui Liu, Fen-Fen Wang, Xian-Jun Peng, Jian-Hui Huang and Shi-Hua Shen
Ludan Zhang, Yuyang Peng, Jian Li, Xinyue Tian and Zhichang Chen
Tuo Qi, Jia Guo, Huan Peng, Peng Liu, Zhensheng Kang and Jun Guo
Wheat and barley are the most highly produced and consumed grains in the world. Various pathogens—viruses, bacteria, fungi, insect pests, and nematode parasites—are major threats to yield and economic losses. Strategies for the management of d... see more
Julia Thom Oxford, Jonathon C. Reeck and Makenna J. Hardy
The evolution of multicellular metazoan organisms was marked by the inclusion of an extracellular matrix (ECM), a multicomponent, proteinaceous network between cells that contributes to the spatial arrangement of cells and the resulting tissue organizatio... see more
Giuseppe Cappellano, Cristoforo Comi, Annalisa Chiocchetti and Umberto Dianzani
Tolerogenic vaccines are aimed at inhibiting antigen-specific immune responses. Antigen-loaded nanoparticles (NPs) have been recently emerged as ideal tools for tolerogenic vaccination because their composition, size, and capability of loading immunomodul... see more
Tânia R. Dias, Luna Samanta, Ashok Agarwal, Peter N. Pushparaj, Manesh Kumar Panner Selvam and Rakesh Sharma