Journal title
ISSN: 1848-7718    frecuency : 4   format : Electrónica

Issues

      see all issue


Skip Navigation Links.

Volume 8 Number Vol. 8 No. 4 (2020) Year 2080

8 articles in this issue 

Luis Castillo-Henríquez, Rolando Vargas-Zúñiga, Jorge Pacheco-Molina, Jose Vega-Baudrit

Electrospinning is a novel and sophisticated technique for the production of nanofibers with high surface area, extreme porous structure, small pore size, and surface morphologies that make them suitable for biomedical and bioengineering applications, whi... see more

 

Shashi Kiran Misra, Kamla Pathak

Approximately two-third of the compounds in the pharmaceutical industry were developed through combinatorial chemistry and high throughput screening of particulate solids. Poor solubility and bioavailability of these pharmaceuticals are challenging attrib... see more

 

David Dahlgren, Erik Sjögren, Hans Lennernäs

An established pharmaceutical strategy to increase oral drug absorption of low solubility–high permeability drugs is to create nanoparticles of them. Reducing the size of the solid-state particles increases their dissolution and transport rate across the ... see more

 

Mauno Vihinen

Solubility is a fundamental protein property that has important connotations for therapeutics and use in diagnosis. Solubility of many proteins is low and affect heterologous overexpression of proteins, formulation of products and their stability. Two pro... see more

 

Jernej Štukelj, Mikael Agopov, Jouko Yliruusi, Clare J. Strachan, Sami Svanbäck

Poor solubility of crystalline drugs can be overcome by amorphization – the production of high-energy disordered solid with improved solubility. However, the improved solubility comes at a cost of reduced stability; amorphous drugs are prone to recrystall... see more

 

Raúl Medina-López, Sergio Guillén-Moedano, Marcela Hurtado

Furosemide is a diuretic drug widely used in chronic renal failure. The drug has low solubility and permeability, which cause clinical problems. Studying the in vitro release performance elucidates the rate and extent of drug dissolved from dosage forms u... see more

 

Daniela Dascalu, Diana Larisa Roman, Madalina Filip, Alecu Aurel Ciorsac, Vasile Ostafe, Adriana Isvoran

Polylactic acid (PLA) is a polymer with an increased potential to be used in different medical applications, including tissue engineering and drug-carries. The use of PLA in medical applications implies the evaluation of the human organism's response to t... see more

 

Tahlia R Meola, Kara Paxton, Paul Joyce, Hayley B Schultz, Clive A Prestidge

Lipid-based formulations (LBFs) are well-known to improve the oral bioavailability of poorly water-soluble drugs (PWSDs) by presenting the drug to the gastrointestinal environment in a molecularly dispersed state, thus avoiding the rate-limiting dissoluti... see more