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ISSN: 2072-6694    frecuency : 4   format : Electrónica


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Volume 11 Number 1 Part January Year 2019

30 articles in this issue 

Souheyla Bensalma, Soumaya Turpault, Annie-Claire Balandre, Madryssa De Boisvilliers, Afsaneh Gaillard, Corinne Chadéneau and Jean-Marc Muller

Glioblastoma (GBM) remains an incurable disease, mainly due to the high migration and invasion potency of GBM cells inside the brain. PI3K/Akt, Sonic Hedgehog (SHH), and PKA pathways play major regulatory roles in the progression of GBM. The vasoactive in... see more


Giovanna Damia and Massimo Broggini

Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. It is initially responsive to cisplatin and carboplatin, two DNA damaging agents used in first line therapy. However, almost invariably, patients relapse with a tumor resistant to su... see more


Mariantonia Logozzi, Davide Mizzoni, Rossella Di Raimo, Daniele Macchia, Massimo Spada and Stefano Fais

Prolonged oxidative stress may play a key role in tumor development. Antioxidant molecules are contained in many foods and seem to have a potential role in future anti-tumor strategies. Among the natural antioxidants the beneficial effect of Fermented Pap... see more


Pawel Swietach and Stefania Monterisi

To produce physiological functions, many tissues require their cells to be connected by gap junctions. Such diffusive coupling is important in establishing a cytoplasmic syncytium through which cells can exchange signals, substrates and metabolites. Often... see more


Barbara Rath, Lukas Klameth, Adelina Plangger, Maximilian Hochmair, Ernst Ulsperger, Ihor Huk, Robert Zeillinger and Gerhard Hamilton

Small cell lung cancer (SCLC) is an aggressive type of lung cancer which disseminates vigorously and has a dismal prognosis. Metastasis of SCLC is linked to an extremely high number of circulating tumor cells (CTCs), which form chemoresistant spheroids, t... see more


Hui Wang, Heng Jiang, Melissa Van De Gucht and Mark De Ridder

Radiotherapy is a mainstay treatment for many types of cancer and kills cancer cells via generation of reactive oxygen species (ROS). Incorporating radiation with pharmacological ROS inducers, therefore, has been widely investigated as an approach to enha... see more


Gopal S. Tandel, Mainak Biswas, Omprakash G. Kakde, Ashish Tiwari, Harman S. Suri, Monica Turk, John R. Laird, Christopher K. Asare, Annabel A. Ankrah, N. N. Khanna, B. K. Madhusudhan, Luca Saba and Jasjit S. Suri

A World Health Organization (WHO) Feb 2018 report has recently shown that mortality rate due to brain or central nervous system (CNS) cancer is the highest in the Asian continent. It is of critical importance that cancer be detected earlier so that many o... see more


Eric Neuhaus, Lisa Zirjacks, Katrin Ganser, Lukas Klumpp, Uwe Schüler, Daniel Zips, Franziska Eckert and Stephan M. Huber

Tumor treating fields (TTFields) represent a novel FDA-approved treatment modality for patients with newly diagnosed or recurrent glioblastoma multiforme. This therapy applies intermediate frequency alternating electric fields with low intensity to the tu... see more


Yao-Hua Liu, I-Jeng Yeh, Ming-Derg Lai, Kuan-Ting Liu, Po-Lin Kuo and Meng-Chi Yen

Dendritic cells (DCs) are capable of activating adaptive immune responses, or inducing immune suppression or tolerance. In the tumor microenvironment, the function of DCs is polarized into immune suppression that attenuates the effect of T cells, promotin... see more


Motomu Shimaoka, Eiji Kawamoto, Arong Gaowa, Takayuki Okamoto and Eun Jeong Park

Connexins and integrins, the two structurally and functionally distinct families of transmembrane proteins, have been shown to be inter-connected by various modes of cross-talk in cells, such as direct physical coupling via lateral contact, indirect physi... see more


Chun-Yu Liu, Pei-Yi Chu, Chun-Teng Huang, Ji-Lin Chen, Hsiu-Ping Yang, Wan-Lun Wang, Ka-Yi Lau, Chia-Han Lee, Tien-Yun Lan, Tzu-Ting Huang, Po-Han Lin, Ming-Shen Dai and Ling-Ming Tseng

Triple-negative breast cancer (TNBC) is a complex disease associated with the aggressive phenotype and poor prognosis. TNBC harbors heterogeneous molecular subtypes with no approved specific targeted therapy. It has been reported that HER receptors are ov... see more


Caroline J. Reddel, Chuen Wen Tan and Vivien M. Chen

The high occurrence of cancer-associated thrombosis is associated with elevated thrombin generation. Tumour cells increase the potential for thrombin generation both directly, through the expression and release of procoagulant factors, and indirectly, thr... see more


Nathalie van den Tempel, Alex N. Zelensky, Hanny Odijk, Charlie Laffeber, Christine K. Schmidt, Inger Brandsma, Jeroen Demmers, Przemek M. Krawczyk and Roland Kanaar

The DNA damage response (DDR) is a designation for a number of pathways that protects our DNA from various damaging agents. In normal cells, the DDR is extremely important for maintaining genome integrity, but in cancer cells these mechanisms counteract t... see more