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17.010  Articles
1 of 1.701 pages  |  10  records  |  more records»
Previously, phosphonic acid derivatives of calix[4]arene and thiacalix[4]arene were found to be potential inhibitors of protein tyrosine phosphatase 1B. In the present paper, the inhibitory activity of unsubstituted sulfonyl-bridget calix[4]arene towards ... see more

Calix[4]arene are known to be a promising scaffold for designing inhibitors of protein tyrosine phosphatases.In this work calix[4]arene mono- and bis-a-hydroxymethylphosphonic acids have been tested in vitro for the inhibitory activity against some therap... see more

A new scoring function H1 recently developed for molecular docking has been tested on the complexes of protein tyrosine phosphatase 1B (PTP1B) from the PDB data bank and using docking of a set of inhibitors from the NIH database. The function is... see more

The protein tyrosine phosphatase (PTP) family is involved in multiple cellular functions and plays an important role in various pathological and physiological processes. In many chronic diseases, for example cancer, PTP is a potential therapeutic target f... see more

The protein tyrosine phosphatase interacting protein 51 (PTPIP51) regulates and interconnects signaling pathways, such as the mitogen-activated protein kinase (MAPK) pathway and an abundance of different others, e.g., Akt signaling, NF-κB signaling,... see more

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Regulation of G2 phase is based on inhibition of MPF (M-phase Promoting Factor) through phosphorylation by Wee1-like kinases. Removal of the inhibiting phosphate group requires Cdc25-like phosphatases. In fission yeast, size control is achieved by mo... see more

The reversible phosphorylation of proteins plays hugely important roles in a variety of cellular processes, such as differentiation, proliferation, and apoptosis. These processes are strictly controlled by protein kinases (phosphorylation) and phosphatase... see more

Cattle milk is a rich source of protein, carbohydrate, vitamins, minerals and all other major and micro nutrients. At a moderate pH, milk is an excellent media for the growth of microbes and thus, intake of raw milk is precarious. In this study, attempt w... see more

1 of 1.701 pages  |  10  records  |  more records»