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15  Articles
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In recent years, targeted therapies have proven beneficial in terms of progression-free survival (PFS) and overall survival (OS) in the treatment of metastatic renal cell carcinoma (mRCC). The tyrosine kinase inhibitors (TKIs) sorafenib and sunitinib are ... see more

Protein tyrosine kinases form an important target for a new class of anticancer drugs, the tyrosine kinase inhibitors (TKIs). Recently we demonstrated that sunitinib, an inhibitor of the membrane-associated vascular endothelial growth factor receptor (VEG... see more

A 55-year old man was treated with sunitinib 50 mg/day for 4 weeks on and 2 weeks off, as a first-line therapy for metastatic renal cell carcinoma. During the fourth week of the first cycle, he was admitted to the Emergency Department with abdominal pain ... see more

Abstract Sunitinib Malate is a multi-targeted receptor tyrosine kinase inhibitor, including the vascular endothelial growth factor receptors, and is used for treatment of pancreatic neuroendocrine, renal cell carcinoma and gastrointestinal str... see more

Introduction: Our study aims to evaluate the use of targeted therapy in metastatic renal cell carcinoma.Methods: This is a prospective study done over three years from December 2010 to December, 2013. Out of Forty seven patients of metastatic renal cell c... see more

Transport of erlotinib, gefitinib, sorafenib, sunitinib, dasatinib and crizotinib can be active or passive, which was studied by measuring uptake  at low (4 °C; passive) and normal temperature (37 °C; active and passive) and by the use of specific or... see more

Tyrosine and aurora kinases are important effectors in signal transduction pathways that are often involved in aberrant cancer cell growth. Tyrosine (TKI) and aurora (AKI) kinase inhibitors are anti-cancer agents specifically designed to target such signa... see more


Gastrointestinal stromal tumors (GISTs) are common mesenchymal neoplasms in the gastrointestinal (GI) tract that need to be differentiated from other GI mesenchymal tumors. They often present with heterogeneous features based on the anatomic locations, hi... see more

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