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10.601  Articles
1 of 1.061 pages  |  10  records  |  more records»
Protein tyrosine kinases form an important target for a new class of anticancer drugs, the tyrosine kinase inhibitors (TKIs). Recently we demonstrated that sunitinib, an inhibitor of the membrane-associated vascular endothelial growth factor receptor (VEG... see more

Transport of erlotinib, gefitinib, sorafenib, sunitinib, dasatinib and crizotinib can be active or passive, which was studied by measuring uptake  at low (4 °C; passive) and normal temperature (37 °C; active and passive) and by the use of specific or... see more

The absorption, efflux and transport properties of two of the most commonly used tyrosine kinase inhibitors (TKIs), Erlotinib (E) and Gefitinib (G) were investigated using an adapted workable methodology of a 3-day Caco-2 cell monolayer transwell system, ... see more

Pharmacokinetics focuses on the question whether a drug actually reaches its target in therapeutic concentrations or accumulates elsewhere, potentially causing toxicological or unpredictable side effects. We determined tissue distribution of gemcitabine, ... see more

Tyrosine kinase inhibitors are a class of chemotherapeutic drugs that target specific protein kinases. These tyrosine kinase inhibitors constitute a relatively new class of drugs which target for instance Bcr-Abl, Epidermal Growth Factor Receptor (EGFR) a... see more

RESUMOMídia é a parte física da informação, que exerce o papel de suporte para diferentes sinais. No entanto, todo sinal que pode ser percebido pelos sentidos do corpo e mentalmente lembrado é também uma marca. Por isso, a mídia suporta e veicula diferent... see more

RESUMOMídia é a parte física da informação, que exerce o papel de suporte para diferentes sinais. No entanto, todo sinal que pode ser percebido pelos sentidos do corpo e mentalmente lembrado é também uma marca. Por isso, a mídia suporta e veicula diferent... see more



1 of 1.061 pages  |  10  records  |  more records»