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19.145  Articles
1 of 1.915 pages  |  10  records  |  more records»
Akt1 is known to promote non-homologous end-joining (NHEJ)-mediated DNA double-strand break (DSB) repair by stimulation of DNA-PKcs. In the present study, we investigated the effect of Akt1 on homologous recombination (HR)-dependent repair of radiation-in... see more

DNA double-strand breaks (DSBs) jeopardize genome integrity and can—when repaired unfaithfully—give rise to structural rearrangements associated with cancer. Exogenous agents such as ionizing radiation or chemotherapy can invoke DSBs, but a va... see more

Blue light is a major component of visible light and digital displays. Over-exposure to blue light could cause retinal damage. However, the mechanism of its damage is not well defined. Here, we demonstrate that blue light (900 lux) impairs cell viability ... see more

Genomic integrity is of outmost importance for the survival at the cellular and the organismal level and key to human health. To ensure the integrity of their DNA, cells have evolved maintenance programs collectively known as the DNA damage response. Part... see more

Fetal Alcohol Spectrum Disorders (FASD) demonstrates increased DNA damage and ultimately apoptosis in neural crest stem cells necessary for early development. In adult alcoholism, neuronal stem cells also demonstrate increased DNA damage from chronic and ... see more

Gamma radiation brings deleterious effects upon human cells by inducing oxidative stress and DNA damages. Antioxidants have been shown to confer protective effects on irradiated normal cells.  Moringa oleifera Lam. is a widely used nutritional supple... see more

Breast cancer is a heterogeneous disease that can be treated by surgery, systemic therapy, and radiotherapy. Adjuvant breast cancer radiotherapy has important implications for patient survival but also causes adverse events. During radiation, not only can... see more

X-rays repair cross-complementing group 1 (XRCC1) gene is one of the gene that plays an important role in base excision repair system (BER) and DNA repair both single and double strand breaks. Individuals with XRCC1 exon 10 (Arg399Gln) gene polymorphisms ... see more

Most bladder tumors have complex genomes characterized by a high mutation burden as well as frequent copy number alterations and chromosomal rearrangements. Alterations in DNA repair pathways—including the double-strand break (DSB) and nucleotide excision... see more

1 of 1.915 pages  |  10  records  |  more records»