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143.445  Articles
1 of 14.345 pages  |  10  records  |  more records»
Genomic integrity is of outmost importance for the survival at the cellular and the organismal level and key to human health. To ensure the integrity of their DNA, cells have evolved maintenance programs collectively known as the DNA damage response. Part... see more

DNA double-strand breaks (DSBs) are deleterious DNA lesions that if left unrepaired or are misrepaired, potentially result in chromosomal aberrations, known drivers of carcinogenesis. Pathways that direct the repair of DSBs are traditionally believed to b... see more

Fetal Alcohol Spectrum Disorders (FASD) demonstrates increased DNA damage and ultimately apoptosis in neural crest stem cells necessary for early development. In adult alcoholism, neuronal stem cells also demonstrate increased DNA damage from chronic and ... see more

Akt1 is known to promote non-homologous end-joining (NHEJ)-mediated DNA double-strand break (DSB) repair by stimulation of DNA-PKcs. In the present study, we investigated the effect of Akt1 on homologous recombination (HR)-dependent repair of radiation-in... see more

How the intestinal absorption of lipids impact dyslipidemias such as obesity and diabetes is currently under debate. NPC1L1 is a critical transport protein in intestinal enterocyte cholesterol absorption. To understand the mechanism of NPC1L1 uptake withi... see more

Meningkatkan Fungsi CRISPR-Cas9 untuk Terapi Pengeditan GenPengeditan gen menjadi mudah dilakukan sejak ditemukannya clustered regularly interspaced short palindromic repeat (CRISPR) dan CRISPR-associated protein 9 (Cas9) sebagai alat untuk menyunting gen... see more

Background: After radiation therapy (RT), some health hazards including DNA damages may occur where melatonin can play a protective role due to free radical generation. On the other hand, serious accidental overexposures may occur during RT due to nuclear... see more

Os rearranjos cromossômicos estruturais são por definição qualquer alteração na estrutura dos cromossomos, ocasionadas por quebras cromossômicas, seguidas ou não, de reconstituição de maneira anômala. O advento das técnicas de citogenética molecular e, no... see more

Homologous recombination (HR) or illegitimate recombination (also known as non-homologous end-joining, NHEJ) are essential for the repair of DNA double strand breaks and cell survival. HR is also an essential part of meiosis, ensuring that new genetic com... see more

1 of 14.345 pages  |  10  records  |  more records»