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2.931  Articles
1 of 294 pages  |  10  records  |  more records»
Transforming Growth Factor-ß (TGF-ß) signaling in cancer has been termed the “TGF-ß paradox”, acting as both a tumor suppresser and promoter. The complexity of TGF-ß signaling within the tumor is context dependent, and greatly impacted by cellular crossta... see more

Nucleoli are emerging as key sensors of cellular stress and regulators of the downstream consequences on proliferation, metabolism, senescence, and apoptosis. NF-κB signalling is activated in response to a similar plethora of stresses, which leads t... see more

Traumatic brain injury (TBI) is a major cause of morbidity and mortality among young individuals worldwide. Understanding the pathophysiology of neurotrauma is crucial for the development of more effective therapeutic strategies. After the trauma occurs, ... see more

The central nervous system (CNS) influences the immune system in a general fashion by regulating the systemic concentration of humoral substances, whereas the autonomic nervous system communicates specifically with the immune system according to local int... see more

The peripheral nervous system communicates specifically with the immune system via local interactions. These interactions include the “hardwiring” of sympathetic/parasympathetic (efferent) and sensory nerves (afferent) to primary (e.g., thymus and bone ma... see more

The NADPH-Thioredoxin System (NTS) and NADPH Glutathione System (NGS) are the two major thiol reduction systems that play a key role in the maintenance of cellular redox homeostasis and several plant developmental processes. Crosstalk between these two th... see more

The G protein-coupled receptor proteinase-activated receptor 2 (PAR2) has been implicated in various aspects of cellular physiology including inflammation, obesity and cancer. In cancer, it usually acts as a driver of cancer progression in various tumor t... see more

The core transcriptional network regulating stem cell self-renewal and pluripotency remains an intense area of research. Increasing evidence indicates that modified regulation of basic cellular processes such as mitochondrial dynamics, apoptosis, and cell... see more

Background: integrins have been associated with the development of chemotherapy resistant tumour cells, mostly those of hematopoietic origin, by mediating the binding to the extracellular matrix. The relevance for solid tumour cells and the underlying mec... see more

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