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2.317  Articles
1 of 233 pages  |  10  records  |  more records»
Colorectal carcinoma (CRC) represents a global health problem. The EGFR signaling pathway is very important in the initiation of different human epithelial cancers and plays a key role in colorectal carcinogenesis. Considering the role of EGFR as a mitoge... see more

Objectives: To compare the clinical effects of Osimertinib and Gefitinib in the treatment of non-small cell lung (NSCLC) complicated with epidermal growth factor receptor (EGFR) gene mutation.Methods: We retrospectively analyzed the clinical data of 102 p... see more

Introduction: Data on the utilisation of epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitors (TKIs) and their clinical outcomes in a heterogeneous Pakistani-Asian population have not been previously reported. This manuscript presents the fi... see more

Paper description: Papillary thyroid carcinoma (PTC), usually curable, sometimes progresses to aggressive forms. Analysis of molecular alterations is helpful in predicting disease course and therapy decisions. BRAF gene mutations and epidermal growth fact... see more

Kinase-targeted cancer therapy (KTCT) with ATP-competitive inhi­bitors has been widely applied in clinics. However, a number of kinase mis­sense mutations were observed to confer acquired drug resistance during ther­apy, largely limiting the clinical appl... see more

Abstrac. Lung cancer is one of the leading causes of death worldwide. Global Cancer Statistic shows the average age of lung cancer is 70 years. Based on the PIONEER study showed high EGFR (Epidermal Growth Factor receptor) mutations in lung adenocarcinoma... see more

This review focuses on adult gliomas, highlighting the most relevant biomarkers in the diagnosis of these tumours and the use of DNA methylation arrays to complement conventional molecular diagnostic techniques. The discovery and characterisation of diagn... see more

Lung cancer is a tumor pathology that includes a group of neoplasms with different biological characteristics, which determine the course of the disease and the potential treatment response depending on the subtype diagnosed. Non-small lung carcinoma corr... see more

Various tyrosine kinase inhibitor (TKI) drugs have been widely used as therapy for cancer that has EGFR mutations, or abnormal EGFR activation. However, patients who have a mutation in the gene that activates EGFR only benefit from EGFR-TKI therapy for le... see more

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