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5.574  Articles
1 of 558 pages  |  10  records  |  more records»
An effective representation of a protein sequence plays a crucial role in protein sub-nuclear localization. The existing representations, such as dipeptide composition (DipC), pseudo-amino acid composition (PseAAC) and position specific scoring matrix (PS... see more

Aspectos clínico e imagenológicos más importantes de los quistes dermoides intrarraquídeos Aspectos clínico e imagenológicos más importantes de los quistes dermoides intrarraquídeosIntroducción: los tumores Dermoides Epidermoides son lesiones que afectan el cráneo y el canal raquídeo, comprimiendo estructuras nerviosas; son infrecuentes y en el Sistema Nervioso corresponden a 1%. Los Quistes dermoides pueden ser congénitos o adquiridos y estar relacionados con malformaciones de la columna vertebral como la espina bífida, la fusión vertebral, los senos dérmicos y la siringomielia. Objetivo: describir los aspectos clínico e imagenológicosmás importantes de los quistes dermoides  intrarraquídeos. Material y Métodos: se realizó un estudio retrospectivo, analítico lineal de 7 casos diagnosticados en el Hospital Pediátrico "William Soler" en el período de noviembre de 2003 a octubre de 2007. Se utilizaron las variables edad, sexo, localización, síntomas, signos  y exámenes de imagen. Resultados: los signos y síntomas más usuales fueron dolor, claudicación a la marcha y el signo de Lasegue; la localización lumbosacra predominó en 87,7%. A todos los pacientes se le realizaron estudios convencionales de Rayos X, a 5 de ellos se les realizó Resonancia Magnética Nuclear y a 2 de ellos se les realizó la Tomografía axial computarizada. Conclusiones: los exámenes imagenológicos realizados a los pacientes estudiados fueron de gran valor para el diagnóstico precoz de la enfermedad.Palabras clave: quiste dermoides, sinovitis de cadera, Resonancia Magnética, Mielo-TAC.ABSTRACTIntroduction: Epidermoid Dermoids tumors are lesions affecting the skull and the rachidial canal compressing nervous structures; are infrequent and corresponding to the 1% of the lesions of Nervous System. Dermoids cysts may be congenital or acquired and been related to vertebral column abnormalities like spina bifida, vertebral fusion, dermic sinus and syringomylia. Objective: to describe the clinical-imageniological aspects of Dermoids cysts.  Material and Methods: an analytic retrospective study of seven cases diagnosed in "William Soler" University Pediatric Hospital during the period from November 2003 to October 2007. Variables used were; age, gender, location, symptoms, signs and image test. Results: the greatest frequency corresponding to male sex and signs and symptoms were pain, walking claudication and Lasegués sign, lumbosacral localization prevail in 87.7% and corresponding tables were designs. Conclusions: we observed the prevalence of the disease in the aged corresponding from 1 to 10 years old, the simple radiological study had a great diagnose value to the patient orientation and diagnose and like specific image study the Magnetic Resonance Image and Myelo- Axial Computer Tomography.Key words: Dermoids Cysts, hip´s synovitis, Magnetic resonance, Myelo- Axial Computer Tomography.

Objetivo: describir los aspectos clínico e imagenológicosmás importantes de los quistes dermoides  intrarraquídeos. Material y Métodos: se realizó un estudio retrospectivo, analítico lineal de 7 casos diagnosticados en el Hospital Pediátrico "Willia... see more

Currently, the practice of nuclear medicine in modern countries comprises a large number of procedures. It is applied to study function of organs/body systems, to visualize, to characterize, and to quantify the functional state of lesions and for targeted... see more

Leptomycin B (LMB) was originally discovered as a potent anti-fungal antibiotic from Streptomyces species. The cellular target of LMB has been identified as the nuclear export receptor CRM-1 or exportin-1, which is involved in nuclear trafficking of cellu... see more

Nuclear transport receptors of the karyopherin superfamily of proteins transport macromolecules from one compartment to the other and are critical for both cell physiology and pathophysiology. The nuclear transport machinery is tightly regulated and essen... see more

In radiation biophysics, it is a subject of nowadays research to investigate DNA strand break repair in detail after damage induction by ionizing radiation. It is a subject of debate as to what makes up the cell’s decision to use a certain repair pathway ... see more

Protein tyrosine kinases form an important target for a new class of anticancer drugs, the tyrosine kinase inhibitors (TKIs). Recently we demonstrated that sunitinib, an inhibitor of the membrane-associated vascular endothelial growth factor receptor (VEG... see more

Alcohol and drug addiction are major problems in today’s society, and specifically in the state of West Virginia. Chronic alcohol exposure has been shown to have various effects on cell proliferation, apoptosis, and DNA damage through oxidative stress. &n... see more

Fetal alcohol Spectrum Disorders (FASD) are associated with reduced proliferation and loss of large numbers of neural crest stem cells.   Previous studies suggest that alcohol increases oxidative stress inducing DNA damage and increasing apoptos... see more

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