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132.503  Articles
1 of 13.251 pages  |  10  records  |  more records»
Senescence is related to the loss of cellular homeostasis and functions, which leads to a progressive decline in physiological ability and to aging-associated diseases. Since mitochondria are essential to energy supply, cell differentiation, cell cycle co... see more

The elimination of abnormal and dysfunctional cellular constituents is an essential prerequisite for nerve cells to maintain their homeostasis and proper function. This is mainly achieved through autophagy, a process that eliminates abnormal and dysfuncti... see more

During the Bronze Age, the cultural region of North Central Iran (NCI) suffered a longterm cultural decline, probably due to severe droughts. According to paleoclimate research, during the overall period c. 5.4–3.5 ka BP, four widely observable climatic e... see more

The insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway is a conserved lifespan-modulating genetic pathway. Many genes involved in lifespan extension associated with decreased signaling of the IIS pathway have been identified. In the presen... see more

One of the main interdisciplinary challenges today is to understand and change the dominant social perceptions and values that support and perpetuate unsustainable practices. Social computational simulations have been conceived in recent years to understa... see more

BACKGROUND: Regardless of the precise underlying molecular mechanisms, the fundamental defining manifestation of aging is an overall decline in the functional capacity of various organs to maintain baseline tissue homeostasis and to respond adequately to ... see more

Background: Tissue culture is a technique to multiply cells or tissue in vitro. With tissue culture cells can be studied as well as the nature of the application. Similarly, tissue culture methods can be applied also to cholesteatoma of chronic ... see more

BACKGROUND: Regardless of the precise underlying molecular mechanisms, the fundamental defining manifestation of aging is an overall decline in the functional capacity of various organs to maintain baseline tissue homeostasis and to respond adequately to ... see more

One of the main sources of reactive oxygen species (ROS) in skeletal muscle is the mitochondria. Prolonged or very high ROS exposure causes oxidative damage, which can be deleterious to muscle function, and as such, there is growing interest in targeting ... see more

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