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6.613  Articles
1 of 662 pages  |  10  records  |  more records»
Conclusions. IFNa-2b can be considered as an auxiliary agent for the development and testing of complex antitumor therapy aimed at activating ?SCs with simultaneous effects of chemotherapy on models of multicellular tumor spheroids of the MCF-7 line, enri... see more

The target effects on the expression of epithelial-mesenchymal transition regulation molecules are promising for cancer therapy, including breast cancer. 3D cell culture is a model for studying epithelial-mesenchymal transition in vitro and may become a t... see more

The target effects on the expression of epithelial-mesenchymal transition regulation molecules are promising for cancer therapy, including breast cancer. 3D cell culture is a model for studying epithelial-mesenchymal transition in vitro and may become a t... see more

Although much research has been carried out on the efficacy of possible breast cancer drug treatments in two-dimensional in vitro cell cultures, these may not adequately represent the response of tumors observed in vivo. As an alternative, multicellular t... see more

Traditionally, the monolayer (two-dimensional) cell cultures are used for initial evaluation of the effectiveness of anticancer therapies. In particular, these experiments provide the IC50 curves that determine drug concentration that can inhibit growth o... see more

Cancer treatment is rapidly evolving toward personalized medicine, which takes into account the individual molecular and genetic variability of tumors. Sophisticated new in vitro disease models, such as three-dimensional cell cultures, may provide a tool ... see more

The epithelial-to-mesenchymal transition (EMT) is an essential trans-differentiation process, which plays a critical role in embryonic development, wound healing, tissue regeneration, organ fibrosis, and cancer progression. It is the fundamental mechanism... see more

Small cell lung cancer (SCLC) is an aggressive type of lung cancer which disseminates vigorously and has a dismal prognosis. Metastasis of SCLC is linked to an extremely high number of circulating tumor cells (CTCs), which form chemoresistant spheroids, t... see more

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