15 articles in this issue
Hannah E. Salapa, Sangmin Lee, Yoojin Shin and Michael C. Levin
Multiple sclerosis (MS) is a demyelinating, autoimmune disease of the central nervous system. In recent years, it has become more evident that neurodegeneration, including neuronal damage and axonal injury, underlies permanent disability in MS. This manus... see more
Paul Tuite
Magnetic resonance imaging (MRI) has the potential to serve as a biomarker for Parkinson’s disease (PD). However, the type or types of biomarker it could provide remain to be determined. At this time there is not sufficient sensitivity or specificity for ... see more
Ricardo Augusto Paoli, Andrea Botturi, Andrea Ciammola, Vincenzo Silani, Cecilia Prunas, Claudio Lucchiari, Elisa Zugno and Elisabetta Caletti
Huntington’s disease is a disorder that results in motor, cognitive, and psychiatric problems. The symptoms often take different forms and the presence of disturbances of the psychic sphere reduces patients’ autonomy and quality of life, also impacting pa... see more
Sheila Glenn
This paper argues that the repetitive behaviour and restrictive interests (RBRI) displayed by individuals with Down syndrome have mostly positive functions. However, as research has developed from interests in Obsessional Compulsive Disorder or Autistic S... see more
Hope Tobin and Elizabeth Race
Learned associations between stimuli and responses (S–R associations) make important contributions to behavioral and neural priming. The current study investigated the automaticity and flexibility of these S–R associations and whether the global task cont... see more
Nicholas A. Hubbard, Yoel Sanchez Araujo, Camila Caballero, Minhui Ouyang, Monroe P. Turner, Lyndahl Himes, Shawheen Faghihahmadabadi, Binu P. Thomas, John Hart, Hao Huang, Darin T. Okuda and Bart Rypma
A multiple sclerosis (MS) diagnosis often relies upon clinical presentation and qualitative analysis of standard, magnetic resonance brain images. However, the accuracy of MS diagnoses can be improved by utilizing advanced brain imaging methods. We assess... see more
Ryoma Morigaki and Satoshi Goto
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat encoding an abnormally long polyglutamine tract (PolyQ) in the huntingtin (Htt) protein. In HD, striking neuropathological c... see more
Ludovic Galas, Magalie Bénard, Alexis Lebon, Yutaro Komuro, Damien Schapman, Hubert Vaudry, David Vaudry and Hitoshi Komuro
Due to its continuing development after birth, the cerebellum represents a unique model for studying the postnatal orchestration of interneuron migration. The combination of fluorescent labeling and ex/in vivo imaging revealed a cellular highway network w... see more
Marc E. Lavoie and Kieron O’Connor
Despite recent giant leaps in understanding Gilles de la Tourette’s syndrome (now Tourette Disorder in the DSM 5), accurate multi-modal description, rigorous assessment procedures, and the improvement of evidence-based treatment currently pose a considera... see more
Julia Irwin, Trey Avery, Jacqueline Turcios, Lawrence Brancazio, Barbara Cook and Nicole Landi
When a speaker talks, the consequences of this can both be heard (audio) and seen (visual). A novel visual phonemic restoration task was used to assess behavioral discrimination and neural signatures (event-related potentials, or ERP) of audiovisual proce... see more
Sean Berman, Toni L. Uhlendorf, David K. Mills, Elliot B. Lander, Mark H. Berman and Randy W. Cohen
Background: This study looked to validate the acoustic wave technology of the Storz-D-Actor that inflicted a consistent closed-head, traumatic brain injury (TBI) in rats. We studied a range of single pulse pressures administered to the rats and observed t... see more
Aina Puce and Matti S. Hämäläinen
Electroencephalography (EEG) and magnetoencephalography (MEG) are non-invasive electrophysiological methods, which record electric potentials and magnetic fields due to electric currents in synchronously-active neurons. With MEG being more sensitive to ne... see more
Clotilde Mircher, Cécile Cieuta-Walti, Isabelle Marey, Anne-Sophie Rebillat, Laura Cretu, Eliane Milenko, Martine Conte, Franck Sturtz, Marie-Odile Rethore and Aimé Ravel
Adolescents and young adults with Down syndrome (DS) can present a rapid regression with loss of independence and daily skills. Causes of regression are unknown and treatment is most of the time symptomatic. We did a retrospective cohort study of regressi... see more
Robert S. Wilson and David A. Bennett
With the aging of the U.S. population, the number of cognitively disabled persons is expected to substantially increase in coming decades, underscoring the urgent need for effective interventions. Here, we review the current evidence linking psychosocial ... see more
Régis Pochon, Claire Touchet and Laure Ibernon
Several studies have reported that persons with Down syndrome (DS) have difficulties recognizing emotions; however, there is insufficient research to prove that a deficit of emotional knowledge exists in DS. The aim of this study was to evaluate the recog... see more