Medical and Clinical Chemistry  

S. K. Shebeko, I. A. Zupanets, T. S. Sakharova

Introduction. Optimization of the treatment of acute kidney injury (AKI) is an important medical and pharmaceutical problem. AKI is a common complication not only of kidney diseases, but also of various treatment methods. Mortality caused by AKI reaches 8... see more

O. O. Shevchuk, A. S. Volska, O. Z. Yaremchuk, Kh. I. Kurylo, K. I. Bardakhivska, V. G. Nikolaev, K. A. Posokhova

Introduction. Anthracyclines are among the most effective anti-cancer and cytotoxic drugs along years. Unfortunately, over the years, its cardiotoxic effects and irreversible heart damage with followed congestive heart failure is still unresolved problem ... see more

T. Yu. Pogorila, S. M. Pashchenko, M. S. Shchurov

Introduction. ?long all molecular genetic types of breast cancer, basal-like tumors account 10–24 %. To carry out more proficient monitoring different biological markers that allow detecting the most aggressive tumors were revealed and applied in practice... see more

V. V. Shcherba, T. Ya. Yaroshenko, A. I. Bandas, M. M. Korda

Introduction. Inflammatory periodontal diseases are one of the most urgent problems of dentistry that have social significance. Along with the known concepts of their pathogenesis, considerable attention is paid to the activation of peroxide oxidation of ... see more

S. V. Buryachenko, B. T. Stegniy

Introduction. Nowadays, the influenza virus is the main cause of diseases for people of all ages, annually leading to death and causing significant economic damage. The virulence and pathogenicity of this virus are largely due to the presence of neuramini... see more

I. M. Podolsky, S. Yu. Shtrygol

Introduction. The object of the present study is atristamine (2-methyl-3-(phenylaminomethyl)-1H-quinolin-4-one), which is being studied as a promising antidepressant with cerebroprotective, nootropic, analgesic, antihypoxic and actoprotective properties. ... see more

M. S. Hnatjuk, N. Ya. Monastyrska, L. V. Tatarchuk

Introduction. Liver resection is widely performed in clinics today. Removal of large amounts of liver leads to various postresection complications and to changes of bile formation.The aim of the study – to learn the peculiarities of bile-forming function ... see more

V. V. Trach, V. V. Danchuk

Introduction. The state of the antioxidant system in animals and birds affects their growth, resistance, productivity and product quality. The biological activity of vitamin E is due primarily to its antioxidant function. a-tocopherol is an active natural... see more

U. O. Mudra, S. M. Andreychyn

Introduction. Gout and non-alcoholic steatohepatitis are common diseases, but the pathogenesis of this combined pathology has not been sufficiently studied.The aim of the study – to investigate the severity of endogenous intoxication, malonedialdehyde con... see more

S. V. Shkurashivska

 Introduction. Stress and its consequences are a serious health problem for a modern human. There are conducted intensive research for ways to reduce the burden on the body. Despite the use the drug Skutellaria in the clinical practice, the metabolic... see more

M. D. Kukhtyn, Z. V. Malimon, T. Ya. Yaroshenko, O. S. Pokotylo

Introduction. Significant and unlimited using of antibacterial drugs in aquaculture, leads to the accumulation of them in the aquatic environment, fish tissues, and accordingly in fish products. Therefore, the question of control of frozen fish entering U... see more

O. Z. Yaremchuk

Introduction. Antiphospholipid syndrome (APS) is one of the most urgent multidisciplinary issues of contemporary medicine. The frequency of kidney damage in cases of APS is 25–78 %.The aim of the study – to investigate the combined effect of L-arginine an... see more

O. B. Kolotylo

Introduction. Obliterating atherosclerosis of the main peripheral vessels accounts for more than 20 % of all cardiovascular pathologies, that is, more than 3 % of the total population. At the present stage, the problem of treating patients with terminal s... see more

N. M. Huzo, N. P. Kovalska, A. R. Grycyk

Introduction. In Ukraine there are four species of plants of the genus Agrimonia L. Of all species, the most common is Agrimonia eupatoria L. The plant has a wide range of pharmacological activity – hepatoprotective, cho­leretic, astringent, anti-inflamma... see more

I. V. Drapak

Introduction. Pharmacophore modeling is one of the most effective virtual screening methods. This method allows to determine the set and relative arrangement of specific molecular fragments that are required for the manifestation of a particular biologica... see more

L. S. Logoyda

Introduction. Analytical method development is increasingly being introduced into fundamental pharmaceutical research, taking into account their high sensitivity, accuracy, specificity and expressiveness. Search criteria was analytical method development ... see more