Medical and Clinical Chemistry  

H. N. Shiyntum, G. A. Ushakova

Introduction. Metal-binding metallothionein genes are found in a vast population of organisms. These proteins are non enzymatic and very rich in cysteine residues. The various metallothionein isoforms in different brain regions arguably change over time.T... see more

V. M. Nechyporuk, N. V. Zaichko, ?. ?. Korda

Introduction. Sulfur-containing amino acids affect the vital processes of cells and methylation processes support the redox potential and integrity of cellular systems, incapacitate toxicants and free radicals. Disorders of sulfur-containing amino acids m... see more

L. O. Kuyun

Introduction. Pathological signs of chronic obstructive pulmonary disease (COPD) is the destruction of the parenchyma with emphysema and inflammation of the small airways. Peritonitis – one of the most frequent pathologies in surgery. It is associated wit... see more

O. B. Furka, I. B. Ivanusa, M. M. Mykhalkiv, I. M. Klishch

Introduction. Acetaminophen has dose-dependent effect on the liver, which is the degree of damage depends on the concentration of this drug in plasma. When administration in large quantities of acetaminophen (accidentally or with suicidal intent) centrolo... see more

O. M. Slivinska, R. J. Iskra

Introduction. Since the diabetes mellitus is a genetically predetermined disease, preventive measures to postpone the onset of the disease or to avert its appearance are especially important for people from risk group. That is why it is so important to ev... see more

D. O. Nekrut, N. V. Zaichko, O. B. Strutinska

Introduction. Evolution of nonalcoholic fatty liver disease (NAFLD) is often accompanied by increased levels of homocysteine, on the other hand hyperhomocysteinemia (HHC) is considered as an independent factor for steatosis and fibrosis of the liver. An i... see more

O. M. Okusok, L. A. Hryshchuk, Z. ?. Nebesna, P. O Tabas, R. O. Klos

Introduction. The liver is one of the most important organs of the human body, performing a number of important functions. Among the common liver diseases, infiltrative pathologies we distinguished: fatty degeneration, lymphomas, amyloidosis, sarcoidosis ... see more

N. V. Lisnianska

Introduction. In the medical literature there are a sufficient number of publications reporting on the relationship between inflammatory bowel disease, colorectal cancer and type 2 diabetes, together with inflammation and dysbiosis. Existing data suggest ... see more

L. S. Logoyda

The aim of this study was the rubustness evaluation of the chromatographic determination of verapamil hydrochloride using Youden’s test.Methods: Youden’s test is a reliable method to evaluate the robustness of analytical methods, by means of an experiment... see more

?. ?. Fedosov, V. S. Kyslychenko, ?. ?. Novosel

Introduction. There are over 12 000 medicinal plants encountered nowadays which are a biogenetically formed complex of biologically active compounds (BAC) and are extensively used in scientific as well as folk medicine. The plants which are used as f... see more

T. A. Zayets, M. I. Marushchak, I. Ya. Pidhaina

Introduction. Many scientific researches were described about functional state of a liver as a model of multiple organ dysfunction in severe conditions of experimental injury. Important sensitive markers of liver failure are: absorption function and excre... see more

J. M. Stepas, L. E. Lapovets, V. M. Akimova, Z. Ya. Lavro

 Introduction. Acute cholecystitis, which is requently complicated by the bile ducts mechanical obstruction, is characterized by a variety of symptoms – from local inflammation to significant changes in hepatocytes and cholestatic intoxication. These... see more

O. Ya. Lavrin, V. V. Shcherba, I. Ya. Krynytska

Introduction. In our days, smoking is one of the most important risk factors for inflammatory diseases. There is a lot of scientific data, devoted to research the effects of smoking on periodontal status. However, some aspects such as the status of free-r... see more

R. M. Liakhovych, M. Ya. Dzus, Ya. M. Kitsak, O. H. Necyuk

Introduction. The article discusses the variety of organophosphorus compounds, ways of their intake, characteristic clinical manifestations and the modern algorithm of pre-hospital therapy in the practice of the emergency medical care brigade (EMC). The r... see more

A. V. Melnik, N. V. Zaichko

Introduction. Sulfur amino acid disorders are recognized as metabolic risk factors for cardiovascular pathology. However, the question of the involvement of sulfur amino acids in the formation of the gender-defined pathology of cardiovascular system remai... see more

L. O. Furdychko

Introduction. The article adduces the obtained results of the indices of immune homeostasis in the development of combined pathology (experimental pneumonia (EP) and gastric ulcer (GU) of the stomach). The immune system is characterized by the n... see more

V. ?. Bondarchuk

Introduction. Mucous membrane of the oral cavity is a sensitive indicator of evaluation of pathological processes of gastrointestinal tract, due to its morphological features difference compared with other mucous membranes. At digestive system diseases, d... see more

I. P. Kuzmak, Ye. B. Dmukhalska, S. R. Pydruchna, T. Ya Yaroshenko, I. Ya. Krynytska, M. I. Kulitska

Introduction. In recent years, scientific articles of domestic and foreign scientists obtained numerical data on the important role of oxidative modification of proteins in the development of many diseases. It is known that entering the organism of toxic ... see more

A. V. Rutska, N. V. Getsko, I. Y. Krynytska

The article analyzes the available literature data on the problem of the food additives usage in the food industry. According to many scientists, reducing the amount of fresh foods that are eaten, and increasing of artificial additives may be one of reaso... see more