26 articles in this issue
M. A. Stashkevych, S. V. Zyablitsev
The main metabolic pathways of anticancer drug 5-fluorouracil (5-FU) include its transformation to activemetabolites via attaching the naturally occurring pentose phosphates. It is known that different tissues use differentnucleosides as donators of pento... see more
Z. L. Savchuk, I. M. Klishch
The article analyzes the efficacy of keratoimplant of pigs in rabbits with corneal chemical burns with underlyingmerkazolil-induced hypothyroidism. Hypothyroidism in rabbits was caused by injection of merkazolil at a dose of10 mg/kg during 60 days. Chemic... see more
?. V. Didenko, H. S. Lisovenko, V. M. Bazas, N. L. Cheremshenko, I. M. Voeykova, O. O. Krutz, H. P. Potebnya
Blood serum of BALB/c mice immunized with chicken embryonic proteins (CEP) in combination with adjuvantsof microbial origin has been investigated by methods of enzyme immunoassay and immunoblotting. The analysisof accumulation of antibodies to CE P and th... see more
V. A. Rybak, L. M. Maloshtan
The conducted research allowed to determine that the tablets “Gliphasonorm” capsules and “Gliphasolin” in anexperimental model of streptozotocin-induced diabetes significantly reduced the level of glycosylated hemoglobin,decreased with the level of glucos... see more
Z. M. Nebesna, ?. S. Volkov, N. Ye. Lisnychuk, ?. Ya. Demkiv
Oxidative stress in the body of the experimental animals after burn injury arises and develops on the backgroundof activation of free radical oxidation and decrease of antioxidant activity and increase of endotoxemia. The combineduse of surfactant prepara... see more
I. I. Zamorskyi, V. M. Drachuk, O. M. Horoshko
The influence of ademetionine (heptral) on the state of prooxidant-antioxidant balance in rats’ kidneys andblood under the conditions of glycerol (rhabdomyolytic) acute renal failure was studied in the experiment. It isestablished, that intraperitoneal ad... see more
D. V. Kozak
In the late period of traumatic disease after trauma (14–28 days) there are observed disimmunological disordermanifested increasing content in serum and CIC immunoglobulin classes A, M, G in terms. Application of Carbacetamfrom the date of trauma for 14 d... see more
O. P. Tsymbala, L. E. Lapovets, V. M. Akimova, O. I. Martyanova
The urgency of the problems caused by frequent research septic complications in patients with acute calculouscholecystitis (ACC), accompanied by increase of endogenous intoxication. The study involved patients with ACCcomplicated with choledocholithiasis,... see more
Ye. B. Dmukhalska, Ya. I. Honsky
The effect of peptide tsysteil-histidil-tyrosil-histidil-isoleucine on the state of antioxidant protection (superoxidedismutase, catalase) and lipid peroxidation has been reached. The peptide exhibits antioxidant activity, the correctionof the peptide red... see more
O. V. Oliynyk, S. O. Savchuk, D. B. Korobko
The article considers insufflation of oxygen, xanthine derivative – salt 3-(8-brom-1,3-dymethyl-2,6-dioxo-2,3-dihidro-1?-purin-7(6?)-il)propanoat (substance “KD-234”) and reamberin efficiency on the parameters of lipidperoxidation (LPO) in middle-steady a... see more
B. F. Yakovlev
A large number of metabolic diseases are the cause of their particular violation. One of these conditions is aviolation of purine metabolism substances. Meaning of purine bases in metabolizme is large since they are part ofpurine nucleotides forming the n... see more
M. P. Zaletsky
Proinflammatory cytokines are produced in response to antigen and tissue damage and stimulate the developmentof local inflammatory response, which is aimed at the elimination of pathogens. When local inflammation is ineffective,these mediators are produce... see more
A. A. Hudyma, I. A. Mykhaylyuk, V. M. Mykhaylyuk
In the period of the early signs of the traumatic disease after the experimental skeletal, cranial-cerebral andcombined traumas the abnormality of the liver biligenetic function occurs, which could be seen by the decrease of thegeneral bile acids forming,... see more
V. A. Par?nik, O. E. Shaulska, V. I. Zhyl?uk, A. I. Shevtsova
In this study we examined the activity of antioxidant enzymes and gelatinases in rats with epinephrine-inducedmyocardial ischemia and the impact of corvitin (C) and doxycycline (D) on these indicators. The administrationof epinephrine (0.2 mg/100 g) for 1... see more
?. Z. Yaremchuk
This study investigated changes of indicators in blood coagulation system and platelet levels in experimentalantiphospholipid syndrome (APS), which was modeled in female mice of the line BALB/c. The results show that thestudy group of the animals with APS... see more
N. M. Volkova
The literature discusses modulation of beta-adrenergic receptors sensitivity of the cerebral cortex under changedconditions for the functioning of the body. However, very little data on the effect of the hypoxic environment to thesensitivity of beta-adren... see more
M. V. Turchyn
The influence of corneal mechanical non-penetrative injury on indices of endogenous intoxication of blood andaqueous humor in rabbits and its correction by ?eratoxenoimplant were studied. It was determined the decrease inthe level of endogenous intoxicati... see more
V. V. Chernyashova
The precursor of the synthesis of nitric oxide – L-arginine at acute peritonitis (intrabdominally administrationnonlinear mature male rats, 25 mg/kg, 30 minutes before and 12, 24 and 36 h after modeling pathology) promoted ofincreasing of nitrite anion co... see more
O. B. Svan
In animals with local ?ryodestruction 10 % of the surface of the skin without xenodermoplast acute stresssignificantly deepens the violation of biligenic liver function values of total bile acids and the degree of conjugationof bilirubin in the bile, whic... see more
O. Y. Zarichna
In experiments on rats with modulated hypothyroidism, acute galactosamine hepatitis, acute hepatitis combinedwith merkazolil-induced hypothyroidism the changes in the indices of free-radical oxidation in blood and liverhomogenate were studied. Results of ... see more
B. O. Mihenko
The results of 123 patients with acute peritonitis were analyzed. All patients were operated in toxic and terminalphases. The indicators of intoxication and enzyme activity of antioxidant system were estimated within 6 hours, 1 and3 days after surgery tre... see more
S. V. Lototska, S. M. Andreychyn, V. M. Meretskyi
The are presented the results of research indicators of immunological status in patients with chronic obstructivepulmonary disease after incluing in the complex therapy of diseases enterosorbents “Enterosgel” or “Karbolayn”.Received results showed that th... see more
?. ?. Koval
The efficacy of simultaneous administration of enterosorbent “Enterosgel” and dietary supplement “Alpha+Omega”in age aspect decreased like that: 1-month > 6-month > 12-month. Such dynamics correlates with degree of rising ofenzymes activity (AST, AL... see more
R. I. Tsytsiura
Modeling of an acute gastric reflex ulcer is accompanied by lipid peroxidation intensification of processes in theliver tissue (increased content of TBA-active products and diene conjugates) and decrease of antioxidant protection(reduced content cerulopl?... see more
I. A. Bandas, I. Ya. Krynytska, M. I. Kulitska, M. M. Korda
In recent years research in various areas of nanoscience in the world and in Ukraine is rapidly developing. Accordingto scientific publications and internet resources authors had analyzed the state of research in various fieldsof nanotechnology, nanomedic... see more
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