Medical and Clinical Chemistry  

N. V. Denysenko, O. Ya. Sklyarov

Introduction. Extensive, and often uncontrolled, use of cyclooxygenase (COX) inhibitors, as well as the psychological stress, are important factors of inflammatory diseases development in the digestive tract, including the large intestine. The activation ... see more

M. S. Hnatjuk, I. V. Bodnarchuk, L. V. Tatarchuk

Introduction. Desquamative glossitis is an inflammatory and dystrophic affect of mucosa of the tongue, which is most common in diseases of the gastrointestinal tract and the hematopoietic system. Desquamative glossitis as an independent pathology is often... see more

H. O. Ushakova, O. Z. Brazaluk, O. Yu. Yevstafieva

Introduction. The critical state of extremely premature newborns is accompanied by significant oxidative stress, which leads to an increase in anaerobic metabolism; impaired oxygen utilization in mitochondrial oxidation may occur due to thiamine deficienc... see more

O. I. Kachur, L. S. Fira, P. H. Lykhatskyi

Introduction. The problem of increasing malignant tumors of the colon is one of the most urgent in the field of medicine. The object of attention in the study of carcinogenesis of the large intestine is the state of the immune system of the organism and t... see more

N. M. Luhinich, I. V. Gerush, N. P. Grygorieva

Introduction. An experimental model of alloxan diabetes mellitus is often used to study the pathogenesis of diabetes. In diabetes, oxidative stress is increased, which leads to depletion of the antioxidant system. Melatonin is an antioxidant and activates... see more

V. V. Shcherba, I. Ya. Krynytska, M. M. Korda

Introduction. In Ukraine, the prevalence of periodontal disease among the population aged 35–44 years ranges from 92 % to 98 %. The question of the hormonal regulation of inflammatory reactions in the periodontium and the characteristics of their developm... see more

O. T. Horodetskyy, M. S. Regeda

Introduction. Development of periodontitis is accompanied by changes in markers of free radical oxidation and antioxidant system in the myocardium, which gradually trigger the processes of lipid peroxidation and compensatorily stimulate the activity of th... see more

I. Ya. Dzyubanovsky, B. M. Verveha, S. R. Pidruchna, N. A. Melnyk, A. A. Hudyma

Introduction. The accumulation of oxidized proteins is considered as one of the factors regulating the synthesis and degradation of proteins, the activation of multicatalytic proteases, which selectively destroy oxidized proteins. It is known that diabete... see more

K. M. Yatsyuk, M. I. Fedorovskaya, S. M. Marchyshyn, L. I. Budniak, L. V. Slobodianiuk

Introduction. Cranberries marsh fruits is a valuable raw material for the development of phyto preparations, which are used in the treatment of urinary tract infections (UTI), colds and dental diseases. Biologically active substances (BAS) contained in th... see more

V. V. Ivchuk, T. A. Kovalchuk

Introduction. The main reason for the failure of the mechanisms of specific and non-specific defense of the body in many diseases and pathological conditions is an imbalance in the system of prooxidants-antioxidants. A significant imbalance in this system... see more

L. S. Logoyda

Introduction. Bioanalytical methodology is the founder of research on bioequivalence and therapeutic drug monitoring, so the focus of the study of pharmacokinetics and bioequivalence should be given to the development and validation of bioanalytical metho... see more

S. V. Maliuvanchuk, A. R. Grytsyk

Introduction. Nowadays, the study of plants which are widespread not only in Ukraine but also throughout the globe is relevant. One of these plants is Ajuga reptans L. It is known that in folk medicine Ajuga reptans L. is used in treating of inflammatory ... see more

O. Ya. Skrynchuk, S. M. Marchyshyn, L. I. Budniak

Introduction. Inappropriate use of natural resources leads to an annual decrease in reserves of wild plants and encourages the use of cultivated flora plants. These plants include the colewort heart-leaved (Crambe cordifolia Steven) and the colewort Kokte... see more

L. V. Drapak

Introduction. The analysis of publications in the leading world chemistry-analytical and pharmaceutical journals allows us to conclude that the researchers are of priority interest in the validation of bioanalytical techniques, as evidenced by the constan... see more

O. O. Kulianda

Introduction. Trauma is one of the causes of oxidative stress. Membrane stabilizing, tread, anti-calcium, antianginal and anti-aggregant properties of xanthines, in particular pentoxifylline, along with other inherent pharmacodynamic effects, can prevent ... see more

Ye. B. Dmukhalska, T. Ya. Yaroshenko

Introduction. Lead poisoning is a major public health risk. Lead is an immunotoxicant, it has reproductive toxicity, liver toxicity. Lead, copper and their compounds exhibit cumulative, cytotoxic effects on the body, cause the activation of oxidative stre... see more

Iu. M. Ordynskyi, O. V. Denefil

Introduction. Determining the mechanisms of damaging the influence of stress on the heart in persons with different reactivity can contribute to the development of individual methods of correction.The aim of the study – to determine the effect of immobili... see more

Tvorchyy Kolektyv

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