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33  Articles
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Introduction. Nowadays, the influenza virus is the main cause of diseases for people of all ages, annually leading to death and causing significant economic damage. The virulence and pathogenicity of this virus are largely due to the presence of neuramini... see more

Introduction. Nowadays, the influenza virus is the main cause of diseases for people of all ages, annually leading to death and causing significant economic damage. The virulence and pathogenicity of this virus are largely due to the presence of neuramini... see more

La influenza A (H1N1): estado actual del conocimiento / Influenza A (H1N1) virus: current informationLa influenza A (H1N1): estado actual del conocimiento / Influenza A (H1N1) virus: current informationSe revisó la bibliografía actualizada sobre el tema a partir de los principales buscadores, y reuniones internacionales realizadas sobre la pandemia de la influenza A (H1N1). Se tratan los aspectos relacionados con la historia, la aparición de la pandemia, la biología de la enfermedad, la epidemiología, el cuadro clínico, el tratamiento y el pronóstico y la prevención. La gripe A (H1N1) es una pandemia causada por una variante nueva del virus de la Influenza A que ha sufrido cambios antigénicos en la hemaglutinina y la neuraminidasa. Esto hace que la población sea altamente vulnerable a la infección y produce una sobrecarga temporal enorme a los servicios de salud. El virus se trasmite como otros virus Influenza. Su letalidad es similar a la de la influenza estacional, pero puede incrementarse en personas con factores de riesgo y en adultos jóvenes sanos. El asma y el embarazo parecen ser condiciones de base importantes para incrementar la severidad de la infección. Puede existir cierta protección por inmunidad cruzada con cepas que circularon en el pasado. El espectro clínico va desde personas asintomáticas hasta las formas graves que requieren internación en cuidados intensivos, con rápido deterioro hasta llegar a la insuficiencia respiratoria en un plazo de 24 horas. La vacunación durante la pandemia no parece ser suficientemente efectiva. Son necesarios antivirales (oseltamivir y zanamivir), y las medidas preventivas higiénico-sanitarias son muy eficaces.Palabras clave: Gripe humana/prevención & y control, Virus de la Influenza A/inmunología/patogenicidad , EPIDEMIOLOGÍA.ABSTRACTAn updated review using the main search motors and international meetings already celebrated related to Influenza A H1N1 pandemics. Items related to the history, the appearance of the pandemics, the biology of the disease, its epidemiology, clinics, treatment, prognosis and prevention. Grippe A H1N1 is a pandemic caused by a new variant of the Influenza A virus that has suffered antigenic changes in haemaglutinin and neuraminidase. This turns populations more susceptible to this infection and produces a temporary burden on the health services. This virus is transmitted like other influenza viruses. Its lethality is similar to that observed for the seasonal influenza, but may be enhanced in people having risk factors and in healthy young adults. Asthma and pregnancy seem to be basic conditions to increase the severity of the infection. Certain degree of protection may exist, due to cross immunity with ancient strains that circulated in the past times. The clinical spectrum goes from asymptomatic people to the most severe forms requiring intensive care, when a rapid deterioration of the health up to reach a respiratory failure in 24 hours. Vaccination during the epidemics seems to be non effective. Antiviral agents (oseltamivir and zanamivir) are necessary, and the preventive hygiene-sanitary measures are highly effective.Key words: Viral disease, influenza, grippe, pandemics, A (H1N1), clinics, epidemiology, treatment, prevention.

ABSTRACTAn updated review using the main search motors and international meetings already celebrated related to Influenza A H1N1 pandemics. Items related to the history, the appearance of the pandemics, the biology of the disease, its epidemiology, clinic... see more

Newcastle disease virus (NDV) is very contagious disease agent, and causes many outbreaks trough out thecountry of Indonesia. This study was conducted to determine the virulence of Bali field isolate of NDVbased on haemaglutinin-neuraminidase (HN) protein... see more

Understanding the conformational dynamics which affects ligand binding by Neuraminidases is needed to improve the in silico selection of novel drug candidates targeting these pathogenicity factors and to adequately estimate the efficacy of potential drugs... see more

Background: Newcastle disease is an important avian infectious disease that brings about vast economic damage for poultry industry. Transgenic plants represent a cost-effective system for the production of therapeutic proteins and are widely used for the ... see more

The viruses that cause avian flu (influenza) are highly contagious and highly variable viruses commonly found in birds. Wild birds in aquatic habitats are thought to be natural reservoirs for influenza viruses, but domestic poultry and other birds can als... see more

Se comparan dos grupos de yeguas FSC en estado fisiológico diferente (preñadas y no preñadas), con el fin de determinar las isoformas de fosfatasa alcalina presentes en el suero sanguíneo. La separación de estas isoformas se realizó por un método comercia... see more

Vaccine sequence of Neuraminidase BTB from previous research was studied by using swiss model server. Protein template was gotten from RSCB database by comparing the vaccine sequence with PDB database. HTY protein was used as a template for this vaccine. ... see more

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