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274  Articles
1 of 28 pages  |  10  records  |  more records»
Objectives: Rasagiline, a drug for Parkinson’s disease is metabolized by CYP1A2 enzyme. The objective of the study was to investigate the influence of cytochrome P450 1A2 variants and smoking status of healthy individuals on the pharmacokinetics of rasagi... see more

Background: Methadone is used for the pain management worldwide. Its special characteristics make it a potential alternative for pain management in critically ill and geriatric patients. Due to lack of studies in this population, we aimed to compare ... see more

Disease states such as hepatitis C and HIV are both associated with methamphetamine (METH) use and are known to produce liver dysfunction. Indeed, bile duct ligation (BDL)-induced liver dysfunction enhances METH effects in rats. While female rats are more... see more

Background. Previous studies showed that new coordinate compound Cerebrogerm (ferrum bis(citrato)germanate) is a promising cerebroprotector.Objective of the study is a comparative analysis of the central stage of the pharmacokinetics of Cerebrogerm as wel... see more

The aim of the study has been evaluation of the pharmacokinetics of fenbendazole molecule, with the experimental protocol for drug testing, using a test (Anipratel) dose of 214.9 mg, compared with a reference (Cestal) dose of 200 mg (table 1). The researc... see more

99mTc-MDP has been developed as a radiopharmaceutical for bone imaging in nuclear medicine. A drug therapy can alter the pharmacokinetic profiles and biodistribution patterns of radiopharmaceuticals. To achieve an optimum diagnostic outcome, this research... see more

Clotting factor concentrates (CFCs) underwent tremendous modifications during the last forty years. Plasma-derived concentrates made the replacement therapy feasible not only in the hospital but also at patients’ home by on-demand or prophylactic regimen.... see more

The paper is devoted to the study of the ion exchange encapsulation of nicotinic acid in nanocontainers on polymer matrices. Dowex-50 cation exchanger, sulphonated polymer based on metacyclophanoctol, polymer zirconium phosphate, and strongly basic Dowex-... see more

One of the primary objectives of physiologically based pharmacokinetics (PBPK) is the prediction of a drug’s pharmacokinetics just from knowledge of its physicochemical structure. Unfortunately, at present, the accuracy of this prediction is limited for m... see more

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