10 articles in this issue
Albertus Budi Sulistya,Rima Haifa,Geofanny Facicilia,Kristin Talia Marbun,Marsya Nilam Kirana,Yussy Afriani Dewi,Cynthia Retna Sartika,Andi Wijaya,Keri Lestari Dandan
BACKGROUND: Dendritic cell (DC)-based cancer therapy is a promising adjuvant therapy for nasopharyngeal cancer (NPC) after chemoradiation. Owing to low immunity after chemoradiation, DC therapy activates immune responses. Moreover, DC-based cancer therapy... see more
Charlene Princess Salvador Tolenada,Geraldine Budomo Dayrit
BACKGROUND: Extended-spectrum ß-lactamase-producing Escherichia coli (ESBL-EC) are selectively proliferated in the human gut, excreted through feces, and deposited through wastewater lines, with hospital wastewater acting as a major reservoir of antibioti... see more
Septelia Inawati Wanandi,Resda Akhra Syahrani,Ayu Suraduhita,Elvira Yunita,Melva Louisa
BACKGROUND: Breast cancer stem cells (BCSCs) have been identified as playing a crucial role in therapeutic resistance. This resistance can be attributed to the anti-apoptotic protein survivin and the antioxidant MnSOD high expression. To overcome the resi... see more
Ria Ambarwati,Damai Santosa,Eko Adhi Pangarsa,Budi Setiawan,Mika Lumban Tobing,Muchlis Achsan Udji Sofro,Dharminto Dharminto,Tjokorda Gde Dalem Pemayun,Catharina Suharti
BACKGROUND: Metabolic syndrome (MetS), which is characterized by insulin resistance, adipocyte accumulation, and obesity, has been linked to malignancy development. Both leptin, an adipose tissue-produced cytokine-like hormone, and adiponectin, a hormone ... see more
Nurul Hidayah,Ika Yustisia,Rosdiana Natzir,Lia Hafiyani,Ilhamuddin Ilhamuddin,Hijral Aswad,Marhaen Hardjo
BACKGROUND: Insufficient glucose levels in colorectal cancer (CRC) patients leads to a condition where fructose might become an alternative source for cells proliferation, but the role of fructose or fructose-glucose combinations in development of CRC has... see more
Hanestya Oky Hermawan,Meity Ardiana,I Gde Rurus Suryawan,Primasitha Maharany Harsoyo,Muhammad Rafli
BACKGROUND: High angiotensin-converting enzyme 2 (ACE2) expression in adipocyte cells facilitates the initiation of SARS-CoV-2 infection and triggers a cytokine storm. This finding suggests that obesity is an independent risk factor for the severity of th... see more
Desty Restia Rahmawati,Arief Nurrochmad,Riris Istighfari Jenie,Edy Meiyanto
BACKGROUND: The anti-cancer properties of pentagamavunon-1 (PGV-1) and curcumin have been documented. This study aimed to evaluate the cytotoxic effect of this combination on breast cancer cell growth using 4T1 and T47D cells, representing triple-negative... see more
Eka Laksmi Hidayati,Bambang Supriyatno,Sudung Oloan Pardede,Partini Pudjiastuti Trihono,Dewi Sukmawati,Dewi Wulandari,Oke Rina Ramayani
BACKGROUND: Nephrotic syndrome (NS) is the most common glomerular disease in childhood. The proposed hypothesis for the pathogenesis of this disease has changed over time, from immune dysregulation theory and systemic circulating factors theory, to the gr... see more
Nur Zam Zam,Harun Iskandar,Nur Ahmad Tabri,Arif Santoso,Nurjannah Lihawa,Harry Akza Putrawan,Ferry Sandra
BACKGROUND: Emergence of drug resistance due to epidermal growth factor receptor (EGFR) Exon 20 T790M poses a challenge in the effective management of non-small cell lung carcinoma (NSCLC). Significant breakthrough in the management of NSCLC with a specif... see more
Fathur Nur Kholis,Nur Farhanah,Charles Limantoro,Nyoman Suci Widyastiti,Mochamad Ali Sobirin
BACKGROUND: Acute respiratory distress syndrome (ARDS) is one of the severe complications of Coronavirus disease 2019 (COVID-19) that can lead to the occurrence of hypoxemia. Hypoxemia occurs due to the role of pro-inflammatory cytokines and coagulation f... see more