13 articles in this issue
Anna Meiliana,Nurrani Mustika Dewi,Andi Wijaya
BACKGROUND: Obesity has been decades become a highly interest study, accompanied by the realization that adipose tissue (AT) plays a major role in the regulation of metabolic function.CONTENT: In past few years, adipocytes classification, development, and... see more
Munar Lubis,Aridamuriany Dwiputri Lubis,Badai Buana Nasution
BACKGROUND: Sepsis in children is a significant cause of morbidity and mortality in the pediatric intensive care unit (PICU). Assessment of pediatric sepsis using serial Pediatric Logistic Organ Dysfunction (PELOD)-2 score can be used as a prognostic fact... see more
Yanuarita Tursinawati,Rifqi Fauzan Hakim,Afiana Rohmani,Arum Kartikadewi,Ferry Sandra
BACKGROUND: The health data of Central Java, Indonesia showed that diabetes mellitus (DM) was the second most increasing non-communicable disease in the province. More than 20 genes have been reported to be associated with DM. Calpain-10 (CAPN10) polymorp... see more
Ami Ashariati Prayogo,Andi Yasmin Wijaya,Winona May Hendrata,Steven Sheng Looi,Reny I’tishom,Lukman Hakim,Fedik Abdul Rantam,I Ketut Sudiana,Abdurachman Abdurachman
BACKGROUND: Cancer stem cells (CSCs) eradication might serve as a robust approach for cancer eradication. MCF-7 as breast cancer continuous cell line is known to contain breast CSCs (BCSCs) for its capability to maintain its original tumor population. CSC... see more
Juminten Saimin,Hartati Hartati,Yenti Purnamasari,Sufiah Asri Mulyawati,Tien Tien,Pranita Ayitrina
BACKGROUND: The access to safe drinkingwater is increasingly difficult, especially in water catchment or coastal areas. Due to the difficulty, people in coastal areas tend to consume ready-to-use refilled drinking-water. However, the sanitation facilities... see more
Ervin Monica,Primayuni Dhia Hasanah,Arief Fadillah,Rara Aulia,Eko Sulistijono,Satrio Wibowo
BACKGROUND: Anemia is frequently found in ulcerative colitis (UC) patients and assumed to be related to inflammatory process. Vitamin D3 (VD) is known to have anti-inflammatory and immunomodulatory effects. It also has the potential to be an alternative t... see more
Astuti Giantini,Dewi Wulandari,Siskawati Suparmin
BACKGROUND: Syphilis and yaws are the treponemal infections which have become serious public health problems, and both are serologically indistinguishable. Developed serological tests for syphilis may also be used to diagnose yaws. In remote area, test mo... see more
Putu Nita Cahyawati,Desak Putu Oki Lestari,Ayu Savitri Siskayani,I Made Toya Ariawan
BACKGROUND: Statin is an anti-cholesterol drug that is widely prescribed throughout the world. Statins are mainly used to treat and prevent cardiovascular disease. Several studies have found the pleiotropic effect of statin. However, related effect of sta... see more
Desy Wulandari,Wisnu Barlianto,Tita Luthfia Sari
BACKGROUND: Vitamin D plays essential role in the regulation of inflammation, such as in pathogenesis of Juvenile Idiopathic Arthritis (JIA). Vitamin D deficiency has been reported among JIA patients, but there were conflicting results regarding the corre... see more
Merlyna Savitri,Ugroseno Yudho Bintoro,Made Putra Sedana,Muhammad Noor Muhammad,Pradana Zaky Romadhon,Putu Niken Ayu Amrita,Andi Yasmin Wijaya,Winona May Hendrata,Ami Ashariati Prayogo
BACKGROUND: Carbohydrate antigens 15-3 (CA 15-3) is a conventional tumor marker in breast cancer, with low sensitivity and specificity. MicroRNA (miRNA)-21 showed its stability in circulation and could serve as powerful biomarker. The aim of this study wa... see more
Sahar Youssef
BACKGROUND: Diclofenac sodium is a nonsteroidal anti-inflammatory prescription, widely used in the management of many inflammatory diseases but the side effects limiting its clinical use. The present work was carried out to detect the ameliorative effect ... see more
I Dewa Gede Ugrasena,Harianto Notopuro,Subijanto Marto Sudarmo,Ketut Sudiana,Djajadiman Gatot,Ponpon Idjradinata
BACKGROUND: Childhood acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy in Indonesia and often treated by methotrexate (MTX). Though it can be cured in 30-60% of patients, MTX resistance remains the major cause of treatment failur... see more
Sela Septima Mariya,Fitriya Nur Annisa Dewi,Eric Hayes,Villiandra Villiandra,Yasmina Arditi Pramastri,Diah Iskandriati,Uus Saepuloh,Joko Pamungkas,I Nengah Budiarsa,Dondin Sajuthi
BACKGROUND: C-C motif Ligand 7 (CCL7) has been reported to be associated with asthma severity in humans. Cynomolgus macaques (Macaca fascicularis; Mf) are often used as animal model of asthma but little is known about Mf genetic profile such as polymorphi... see more