13 articles in this issue
Anna Meiliana,Nurrani Mustika Dewi,Andi Wijaya
BACKGROUND: Metastases are simply known as cancers spread to another part of the body, and often be responsible for the severity of cancer prognosis. Somehow, the complex mechanisms of metastases are not fully understood yet.CONTENT: The characteristic of... see more
Marwa Magdy Hamido,Nashwah Ismail Zaki,Sawsan Ahmed Nasr,Wael Mohamed El-Sayed
BACKGROUND: The interaction of carbamazepine (CBZ) and acetaminophen (APAP) could result in hepatic failure and mortality. This study was conducted to analyzed the potential of rosemary ethanol extract (REE) or coenzyme Q10 (CoQ10) to alleviate the intera... see more
Ferry Sandra,Muhammad Ihsan Rizal,Caecilia Caroline Aliwarga,Jenifer Christy Hadimartana,Maria Celinna
BACKGROUND: Caffeic acid has been reported to activate caspases in MG-63 osteosarcoma cells, which can lead to apoptosis via both extrinsic and intrinsic apoptotic pathways. Translocation of protein kinase C delta (PKCd), which reduces mitochondrial membr... see more
Sri Nabawiyati Nurul Makiyah,Masaki Kita,Ika Setyawati,Sri Tasminatun
BACKGROUND: Dioscorea alata L. tubers (DA) are suspected to prevent diabetes mellitus (DM) because they have a low glycemic index. However, only a few reports about the anti-diabetic effect of DA were reported up to date. This study aims to analyze the ef... see more
Annisa Annisa,Elizabeth Henny Herningtyas,Dewajani Purnomosari
BACKGROUND: Hypoxia adaptation in cancer cells is mediated by hypoxia inducible factor (HIF)-1 that induces the expression of various proteins. Up to date, the analysis of T47D breast cancer cells-secreted protein is still limited. The aim of this study w... see more
Soraya Rahmanisa,Ekavianty Prajatelistia,Indra Wibowo,Anggraini Barlian
BACKGROUND: Biosilica derived from Indonesian marine sponge Melophlus sarasinorum and Xestospongia testudinaria is one of the biomaterials that can be developed together with synthetic polymer as a composite. Poly E-caprolactone (PCL) used as a composite ... see more
Iskandar Rahardjo Budianto,Agus Firmansyah,Yefta Moenadjat,Ahmad Aulia Jusuf,Vivian Soetikno
BACKGROUND: Many hypotheses regarding the pathophysiology of enterocolitis in aganglionic megacolon or Hirschsprung disease (HSCR) has been proposed. Paneth cells are columnar intestinal epithelial cells that have an important role in maintaining of intes... see more
Banun Kusumawardani,Larissa Tania,Ari Satia Nugraha
BACKGROUND: Cervical cancer has a high rate of morbidity and mortality in women with cancer. Recent studies have found that tobacco (Nicotiana tabacum L.) is a potential source of anti-cancer agents. Hence, this study was conducted to determine the potent... see more
Mardhatillah Sariyanti,Tiara Ayoe Andita,Noor Diah Erlinawati,Elvira Yunita,Ahmad Azmi Nasution,Kartika Sari,Nikki Aldi Massardi,Sylvia Rianissa Putri
BACKGROUND: Intestinal microbial dysbiosis and its metabolites can affect the immune activity of intestinal mucosal cells, causing insulitis and pancreatic ß-cell death. Probiotic Lactobacillus acidophilus plays an important role in reducing inflammatory ... see more
Ferry Sandra,Dewi Ranggaini,Laifa Annisa Hendamin,Nurrani Mustika Dewi,Melanie Sadono Djamil
BACKGROUND: Formation of tumour mass is one symptom of osteosarcoma development. Caffeic acid has been known to provide effective treatment but has less side effect for some cancer therapy. Studies reported that caffeic acid might promote apoptosis in MG-... see more
Wilya Isnaeni,Suryani As'ad,Mochammad Hatta,Saidah Syamsuddin,Fahrin Ramadan Andiwijaya,Hamsu Kadriyan
BACKGROUND: Cases of undernutrition, such as stunting and wasting, in Nusa Tenggara Barat (NTB), Indonesia, was found to be relatively high. Therefore, local government launched a golden generation program called GEN NTB to improve the quality of human re... see more
Jonathan Alvin Nugraha Halim,Endang Sri Lestari,Sigit Adi Prasetyo,Muflihatul Muniroh,Agung Aji Prasetyo
BACKGROUND: Cholestasis caused by obstruction of the common bile duct and may developed gut-derived sepsis due to reactive oxygen species (ROS) accumulation. Ursodeoxycholic acid (UDCA) and glutathione are widely known for their antioxidant properties, th... see more
Pieri Kumaladewi,Wirsma Arif Harahap,Bastian Nova,Irianiwati Widodo,Ramadhan Karsono,Ferry Sandra,Bethy Suryawathy Hernowo
BACKGROUND: Interaction between estrogen and estrogen receptor (ER) takes part in the regulation and differentiation of breast tumorigenesis. Some ERa polymorphisms, including ERa rs3798577, are reported to be associated with the risk and aggressiveness o... see more