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120  Articles
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Acute myeloid leukemia (AML) is a heterogeneous group of diseases with a multitude of molecular genetic aberrations and variable clinical outcome. Clonal chromosomal abnormalities have been identified in over 50% of AML cases, and have been regarded as on... see more

196 samples of removed thyroid gland tissue were studied. The expression of p53, p21WAF1/CIP1, p63, and proliferation marker Ki-67 were studied in the sections. The greatest increase in expression level of p53, p63, Ki-67 and p21WAF1/CIP1 in comparison wi... see more

Phosphorylation of H2AX on Ser139 (?H2AX) after exposure to ionizing radiation produces nuclear foci that are detectable by immunofluorescence microscopy. These so-called ?H2AX foci have been adopted as quantitative markers for DNA double-strand breaks. H... see more

The oncogenic cytoplasmic p21 contributes to cancer aggressiveness and chemotherapeutic failure. However, the molecular mechanisms remain obscure. Here, we show for the first time that cytoplasmic p21 mediates 5-Fluorouracil (5FU) resistance by shuttling ... see more

Anaplastic thyroid carcinoma is highly invasive with a poor response to a treatment. In this study, curcumin bioavailability and its effects on apoptosis induction and selected genes expression of the human anaplastic thyroid carcinoma cell line (SW-1736)... see more

Purpose: Head and neck tumours include tumours of nose, paranasal sinuses, oropharynx, larynx and mouth. Squamous cell carcinoma (SCC) is the most common head and neck malignant tumour which accounts for 90% of head and neck malignant tumours. p21 is an i... see more

Acute myeloid leukemia (AML) is a heterogeneous group of diseases with a multitude of molecular genetic aberrations and variable clinical outcome. Clonal chromosomal abnormalities have been identified in over 50% of AML cases, and have been regarded as on... see more

Breakpoint cluster region-abelson (BCR-ABL) leukemic fusion gene types in chronic myeloid leukemia (CML) correlate with the disease clinical course and outcome. There are variations in the reports of previous studies about the frequencies and distribution... see more

128 samples of removed thyroid gland tissue were studied. In all cases differentiated thyroid cancer was diagnosed. We analyzed the results of immunohistochemical staining for p53, p21WAF1/CIP1 and p63 and the correlation with presence and type of patient... see more

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