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42.238  Articles
1 of 4.225 pages  |  10  records  |  more records»
Molecular mechanism research is a fascinating area involving multidisciplinary scientists. This study offers insight into the characterization of protein interactions, which is an important subject of this research. The discussion covers case st... see more

The prediction of Compound-Protein Interactions (CPI) is an essential step in drug-target analysis for developing new drugs. Therefore, it needs a good incentive to develop a faster and more effective method to predicting the interaction between compound ... see more

Parkinson’s disease is the next frequent neurodegenerative disorder after Alzheimer’s, caused primarily by the loss of dopaminergic neurons of the Substantia Nigra. Mutations in the Putative-induced Kinase - a mitochondrial Serine/Threonine-protein Ki... see more

Here, we investigate the strengths of R–X···p interactions, involving both chlorine and bromine, in model systems derived from protein-ligand complexes found in the PDB. We find that the strengths of these interactions can vary significantly, with binding... see more

Some of the intrinsically disordered proteins and protein regions are promiscuous interactors that are involved in one-to-many and many-to-one binding. Several studies have analyzed enrichment of intrinsic disorder among the promiscuous hub proteins. We e... see more

Intrinsically disordered protein YAP (yes-associated protein) interacts with TEADs transcriptional factors family (transcriptional enhancer associated domain) creating three interfaces. Interface 3, between the Ω-loop of YAP and a shallow pocket of ... see more

Proteomics research has become one of the most important topics in the field of life science and natural science. At present, research on protein–protein interaction networks (PPIN) mainly focuses on detecting protein complexes or function modules. Howeve... see more

During the last decades growing attention has been paid to ascertaining the factors responsible for the toxic potential of particular protein aggregates, amyloid fibrils, whose formation is associated with a range of human pathologies, including the neuro... see more

Self-assembly of proteins and peptides into amyloid fibrils is the subject of intense research due to association of this process with multiple human disorders. Despite considerable progress in understanding the nature of amyloid cytotoxicity, the role of... see more

1 of 4.225 pages  |  10  records  |  more records»