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403.472  Articles
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Physiologically based pharmacokinetic (PBPK) modeling is a mechanistic or physiology based mathematical modeling technique which integrates the knowledge from both drug-based properties including physiochemical and biopharmaceutical properties and system ... see more

The interest in using physiologically-based pharmacokinetic (PBPK) models as a support to the drug development decision making process has rapidly increased in the last years. These kind of models are examples of the “bottom up” modelling strategy, which ... see more

The present studies discuss about the quality by design (QbD)-based development and evaluation of chronomodulated release drug delivery system of amoxicillin trihydrate for management of bacterial infection. Initially, target product profile was defined a... see more

Objectives: Accurately identifying the cellular, biomolecular, and toxicological functions of anticancer drugs help to decipher the potential risk of genotoxicity and other side effects. Here, we examined bleomycin for cellular, molecular and toxicologica... see more

The estrogen receptor alpha (ERa) plays an important role in breast development and pro-proliferation signal activation in the normal and cancerous breast. The ERa inhibitors were potentially active as cytotoxic agents against breast cancer. This study wa... see more

Drug-drug interactions (DDIs) are responsible for many serious adverse events; their detection is crucial for patient safety but also very challenging. In recent years, several drugs have been withdrawn from the market due to interaction related Adverse E... see more

Diabetes mellitus (DM) is a widespread metabolic disease with a progressive incidence of morbidity and mortality worldwide. Despite extensive research, treatment options for diabetic patients remains limited. Although significant challenges remain, induce... see more

Molecular modeling by means of docking and molecular dynamics (MD) has become an integral part of early drug discovery projects, enabling the screening and enrichment of large libraries of small molecules. In the past decades, special emphasis was drawn t... see more

This research is to development learning model smash volleyball based multiple training in State University of Medan. This method was research and development/R & D proposed by Borg and Gall (2005). Based on trial results found, multiple based learning mo... see more

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