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7.133  Articles
1 of 714 pages  |  10  records  |  more records»
Several studies have shown that different control plasmids may cause antitumor action in different murine tumor models after gene electrotransfer (GET). Due to the differences in GET protocols, plasmid vectors, and experimental models, the observed antitu... see more

In the past few decades, research in new drugs for treatment of oncological disorders has refocused on naturally occurring products. Among various plant-derived compounds flavonoids are considered as promising chemopreventive and chemotherapeutic agents e... see more

Plasmids, which are currently used in interleukin 12 (IL-12) gene electrotransfer (GET) clinical trials in the USA, contain antibiotic resistance genes and are thus, according to the safety recommendation of the European Medicines Agency (EMA), not suitab... see more

Prolonged oxidative stress may play a key role in tumor development. Antioxidant molecules are contained in many foods and seem to have a potential role in future anti-tumor strategies. Among the natural antioxidants the beneficial effect of Fermented Pap... see more

Recently, combination therapies involving interleukin-12 (IL-12) gene delivery and 4-1BB targeted immunotherapy have proven especially fruitful in treating multiple cancers such as melanoma, breast carcinoma, colon carcinoma and so on in murine models. We... see more

Pannexin 1 (PANX1) is a channel-forming glycoprotein expressed in many tissues including the skin. PANX1 channels allow the passage of ions and molecules up to 1 kDa, including ATP and other metabolites. In this study, we show that PANX1 is highly express... see more

Conjunctival melanoma is an uncommon tumor of the ocular surface, representing only 1.6% of all non-cutaneous melanomas.1 Overall metastasis rates range from 14-27%, with 10-40% of which arising in the central nervous system (CNS).1,2 CNS involvement has ... see more

Although neurotropism and focal neural differentiation are fairly common in the setting of desmoplastic and spindle cell melanoma, in situ melanoma exhibiting a significant well differentiated neural component is very rare. We report the case of a 70 year... see more

Cutaneous collision tumors are known as two independent tumors which are close anatomically and separated from one another by well boundaries. We, herein report a 83-year-old female patient with two cutaneous collision tumors in two different localization... see more

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