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13  Articles
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A highly enantioselective organocatalytic Wolff rearrangement–amidation–Michael–hemiaminalization stepwise reaction is described involving a cyclic 2-diazo-1,3-diketone, primary amine and a,ß-unsaturated aldehyde. Product stereocontrol can be achieved by ... see more

A convenient and efficient method for the synthesis of new unsaturated spiro-annulated N-aryl-4,6-dioxopyrimidine-2-thione derivatives has been developed. The resulting compounds can be potential biological active molecules or precursors for further chemi... see more

The article describes the study of the antihypoxic action of the compounds previously synthesized, namely indole and 2-oxindole derivatives, containing an ethylamine fragment being characteristic of melatonin, and the “chemical structure – antihypoxic act... see more


Aim. To synthesize the series of new spiro[indole-3,1’-pyrrolo[3,4-c]pyrrole]-2,4’,6’-trione derivatives, study their physicochemical characteristics, antibacterial activity and precision of the molecular docking on the model of staphylococcal dehydrosqua... see more

The present article describes the synthesis of novel spiro-condensed [1,2,4]triazolo[1,5-c]quinazolines. [2-(3-Aryl1H-1,2,4-triazol-5-yl)phenyl]amines were used as effective precursors for the synthesis of the compounds mentioned above. The experimental d... see more

Aim. To synthesize the series of new spiro[indole-3,1’-pyrrolo[3,4-c]pyrrole]-2,4’,6’-trione derivatives, study their physicochemical characteristics, antibacterial activity and precision of the molecular docking on the model of staphylococcal dehydrosqua... see more

Aim. To develop the preparative methods for obtaining new series of biologically active substances by the three-component interaction between isatin, a-amino acids and N,N’-di(3-carboxypropenoyl)-1,2-ethylenediamine and determine the structure of the comp... see more

Aim. To synthesize new derivatives based on hexamethylene(ethylene)-N,N’-bis(spiroindole-3,3’-pyrrolo-[3,4-c]pyrrole-2a,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trions) and 1’-(m-phenylene-N-maleimidido)-2a’,5a’-dihydro-1’H- spiroindole-3,3’-pyrrolo[3,4-c]pyrrole-... see more

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