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Validated LC-ESI-MS/MS method for the determination of ivosidenib in 10 µL mice plasma: application to a pharmacokinetic study

Sreekanth Dittakavi, Rakesh Kumar Jat, Sadanand Rangnathrao Mallurwar, Ravi Kumar Jairam, Ramesh Mullangi

A simple, selective and rapid LC-ESI-MS/MS method has been developed and validated for the quantification of ivosidenib in mice plasma using warfarin as an internal standard (I.S.) as per regulatory guideline. Sample preparation was accomplished through a... see more

ADMET and DMPK , 2019

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Validated HPLC method for quantification of copanlisib in mice plasma: application to a pharmacokinetic study

Ashok Zakkula, Pavan Kumar Kurakula, Sreekanth Dittakavi, Prasanthi Daram, Ram Murthi Bestha, Mohd Zainuddin, Ravi Kumar Trivedi, Ramesh Mullangi

Copanlisib is a pan phosphatidylinositol 3-kinase (PI3K) inhibitor approved for follicular lymphoma. In this paper, we present the data of development and validation of a high-performance liquid chromatography (HPLC) method for the quantitation of copanli... see more

Copanlisib | HPLC | method validation | mice plasma | pharmacokinetics

ADMET and DMPK , 2020

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Bioenhancing effects of naringin on atrovastatin

Sama Venkatesh, Balaraju Pagilla, Rajeswari Chiluka, Ravi Alvala, Ravi Kumar Pola, Ramesh Mullangi

Naringin (CAS no: 10236-47-2) is a flavonone glycoside obtained from Citrus paradisi (grapefruit), a natural bioenhancer and reported to enhance the bioavailability of drugs by inhibiting cytochrome P450 and P-glycoprotein (P-gp). The aim of the present s... see more

ADMET and DMPK , 2038

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Utilization of Terminalia chebula Retz. fruits pericarp as a source of natural dye for textile applications

Onial, Praveen ;Dayal, Rameshwar ;Rawat, M S M;Kumar, Rakesh

Indian Journal of Natural Products and Resources , 2015

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A review on the important phytochemicals and their role in psoriasis

Ashish Pandey, Alok Kumar Shukla, Ramesh Chandra Dubey, Ravi Pratap

Journal of Applied and Natural Science , 2021

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Development and validation of a novel method for simultaneous quantification of enzalutamide, darolutamide and their active metabolites in mice dried blood spots using LC-MS/MS: Application to pharmacokinetic study in mice

Neeraj Kumar Saini, Suresh P Sulochana, Mohd Zainuddin, Ramesh Mullangi

A simple, sensitive and rapid assay method has been developed and validated for the estimation of enzalutamide, N-desmethylenzalutamide (active metabolite of enzalutamide), darolutamide and ORM-15341 (active metabolite of darolutamide) on mice dried blood... see more

ADMET and DMPK , 2018

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Preclinical assessment of ulixertinib, a novel ERK1/2 inhibitor

Vinod Anera Balakrishna, Anitha Police, Rakesh Hiremath, Anusha Raj, Suresh P Sulochana, Devaraj V Chandrasekhar, Zainuddin Mohd, Ravi Kanth Bhamidipati, Ramesh Mullangi

Ulixertinib (BVD-523) is a novel and selective reversible inhibitor of ERK1/ERK2. In xenograft studies it inhibited tumor growth in BRAF-mutant melanoma and colorectal xenografts as well as KRAS-mutant colorectal and pancreatic models. Ulixertinib is curr... see more

ADMET and DMPK , 2033

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Impact of Foliar Fertilization on Leaf Nutrient Status of Kinnow Mandarin

. Reetika, G. S. Rana, Rakesh Kumar, Ravi Kumar

International Journal of Plant & Soil Science , 2020

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MODERN STATE OF CREATION, PRODUCTION AND RESEARCH OF DRUGS

I. V. Kozak, M. B. Demchuk, T. A. Hroshovyi

MODERN STATE OF CREATION, PRODUCTION AND RESEARCH OF DRUGSI.V. Kozak, M.B. Demchuk, T.A. HroshovyiI.HorbachevskyTernopilStateMedicalUniversityIntroduction. Creating new systems and drug delivery aimed at increasing the effectiveness and safety of treatmen... see more

Pharmaceutical Review , 2016

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