ARTICLE
TITLE

The Pivotal Novel Pathogenic Roles of Hyaluronic Acid and its Receptors in Gliomas

SUMMARY

HA/CD44 as well as HA/RHAMM cross-talks resulted in glioma cell adhesion, mechanosensing, as well as invasive motility. RHAMM was overexpressed in DIPG and may contribute to the diffuse growth pattern and invasion in DIPG just like other forms of gliomas other than CD44. BEHAB/brevican could be a potential biomarker for glioma detection as well as its progression or malignancy.

KEYWORDS

 Articles related

Feng He and Li Zuo    

Cardiovascular disease (CVD), a major cause of mortality in the world, has been extensively studied over the past decade. However, the exact mechanism underlying its pathogenesis has not been fully elucidated. Reactive oxygen species (ROS) play a pivotal... see more


Yi Pang, Lu-Tai Tien, Hobart Zhu, Juying Shen, Camilla F. Wright, Tembra K. Jones, Samir A. Mamoon, Abhay J. Bhatt, Zhengwei Cai and Lir-Wan Fan    

Our previous study showed that a single lipopolysaccharide (LPS) treatment to neonatal rats could induce a long-lasting neuroinflammatory response and dopaminergic system injury late in life. This is evidenced by a sustained activation of microglia and e... see more


Milena Rondón-Lagos, Victoria E. Villegas, Nelson Rangel, Magda Carolina Sánchez and Peter G. Zaphiropoulos    

17ß-Estradiol (E2) plays a pivotal role in the development and progression of breast cancer. As a result, blockade of the E2 signal through either tamoxifen (TAM) or aromatase inhibitors is an important therapeutic strategy to treat or prevent estrogen r... see more


Neha Rathi, Lynn Riddell and Anthony Worsley    

School food environments and policies can play a pivotal role in inculcating healthy food habits among young people. This cross-sectional survey explored teachers’ and parents’ views of the role of school food environments and policies in pro... see more


Angelina Lo Giudice and Carmen Rizzo    

The ecological function of bacteria-invertebrate interactions in Polar areas remains poorly understood, despite increasing evidence that microbial metabolites may play pivotal roles in host-associated chemical defense and in shaping the symbiotic communi... see more

Revista: Diversity