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1.608.248  Articles
1 of 160.826 pages  |  10  records  |  more records»
Background: Escherichia coli has been widely used as a host to clone and express heterologous genes. However, there are few vectors available for cloning and expressing extremely toxic genes, which limits further basic and applied research on extremely to... see more

Background: This study was aimed to silencing the Nucleoside transporter 3 (NT3) permease nucleobases involved in the salvage pathway of Leishmania in order to disrupt purine nucleotide uptake in the parasite and consequently, destruction of the parasite.... see more

The Tetracycline regulatory system is based on the Tet repressor protein (TetR) of the Escherichia coli Tn10 tetracycline (Tc) resistance operon and its operator (tetO) (Hillen and Berens, 1994). TetR blocks transcription of these genes by binding to the ... see more

Regulation of gene expression is achieved by sequence-specific transcriptional regulators, which convey the information that is contained in the sequence of DNA into RNA polymerase activity. This is achieved by the recruitment of transcriptional co-factor... see more

Genomic imprinting occurs where only one allele of a gene is expressed depending on its parental origin. The imprinted Igf2 gene (Insulin-like growth factor 2) is encoding a growth factor, which play an important role in embryonic development and formatio... see more

Chronic obstructive pulmonary disease (COPD) is an independent risk factor for the development of lung cancer. Several pathogenic pathways such as oxidative stress and chronic inflammation of the lower airways are shared by these two diseases. The RNA-bin... see more

Anti-apoptotic B cell lymphoma 2 (BCL2) family members (BCL2, MCL1, BCLxL, BCLW, and BFL1) are key players in the regulation of intrinsic apoptosis. Dysregulation of these proteins not only impairs normal development, but also contributes to tumor progres... see more

Background: Ethylene plays an important role in the regulation of floral organ development in soybean, and 1-aminocyclopropane-1-carboxylate synthase (ACS) is a rate-limiting enzyme for ethylene biosynthesis. However, whether ACS also regulates floral org... see more

The thyroid hormone plays a key role in energy and nutrient metabolisms in many tissues and regulates the transcription of key genes in metabolic pathways. It has long been believed that thyroid hormones (THs) exerted their effects primarily by binding to... see more

1 of 160.826 pages  |  10  records  |  more records»