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3.759  Articles
1 of 377 pages  |  10  records  |  more records»
Background: Conjugated linoleic acid (CLA) is an effective supplement for reducing fat mass, but its effect on hepatic steatosis remains controversial.Objective: This study aims to evaluate the effect of CLA on liver fat accumulation, inflammati... see more

The objective of this study was to design and develop microemulsion drug delivery system of Atorvastatin and to investigate its intestinal transport behavior using the single-pass intestinal perfusion method in rat. Microemulsion drug delivery system of A... see more

Introduction and purpose: Protective function, immune and nutrition in the human body correspond to the intestinal barrier. As a result of excessive exposure to various factors often leads to damage or abnormalities in its functioning, which negatively af... see more

P-glycoprotein (P-gp) is a membrane transporter responsible for the active efflux from the cell. Inhibition of the activity may lead to clinically significant drug-drug interactions. This study was performed to investigate the effects of atorvastatin and ... see more

Background: We assessed the feasibility of using crystal-liquid fugacity ratio (CLFR) as an alternative parameter for intestinal permeability in the biopharmaceutical classification (BCS) of passively absorbed drugs. Methods: Dose number, fraction of dose... see more

Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the sacroiliac joints and the spine, for which the pathogenesis is thought to be a result of the combination of host genetic factors and environmental triggers. However, the... see more

Objective. Determine the levels of plasma intestinal fatty acid binding proteins levels in combination with zonulin in patients with generalized intra-abdominal infection and abdominal sepsis, and define the clinical usefulness them to assess the severity... see more

An established pharmaceutical strategy to increase oral drug absorption of low solubility–high permeability drugs is to create nanoparticles of them. Reducing the size of the solid-state particles increases their dissolution and transport rate across the ... see more

Introduction: Eating disorders are severe psychiatric disorders. Anorexia nervosa (AN) has a mortality rate among the highest of any psychiatric illnesses. Anorexia nervosa is characterised by extreme weight loss and fear of gaining weight. Lifestyle and ... see more

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