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8  Articles
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Tofacitinib es un inhibidor de JAK-quinasa indicado en el tratamiento de la artritis reumatoide (AR), pudiendo administrarse en monoterapia cuando se ha producido fallo o intolerancia a FAMEs y/o anti-TNF. Por otro lado se debe tener en cuenta un balance ... see more

BACKGROUND: Vitiligo is an acquired pigmentary cutaneous disease, characterised by the progressive loss of melanocytes, resulting in hypopigmented skin areas which progressively become amelanotic. Classically, vitiligo treatments are unsatisfactory and ch... see more

Os inibidores das Janus Associated Kinases (JAK) são uma estratégia recente direcionada para o tratamento de diversas patologias como a artrite reumatoide, a psoríase, a alopecia areata e diversos tipos de cancro. Contudo, estes medicamentos estão associa... see more





Filgotinib is a selective JAK1 (Janus kinase) inhibitor, showed efficacy in patients suffering from moderate-to-severe rheumatoid arthritis. In this paper, we present the data on the development and validation of a sensitive, selective and high-throughput... see more

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