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47.807  Articles
1 of 4.782 pages  |  10  records  |  more records»
Background: Patients with inflammatory joint diseases (IJD) have an increased risk of cardiovascular disease (CVD) compared to the general population. Nutritional advice has been shown to influence CVD risk factors. Our objective was to evaluate whether a... see more

Musculoskeletal manifestations are one of the most frequent extraintestinal manifestations of inflammatory bowel disease (IBD). Inflammatory of joints in IBD, both peripheral and axial arthopathies, belong to the spondyloarthritis group (SpA). The prevale... see more

Extraintestinal manifestations (EIMs) in patients with inflammatory bowel diseases (IBD) are immuno-mediated conditions that may occur in up to 50% of IBD patients. Several organ systems may be involved such as joints, skin, liver, and eyes. EIMs may occu... see more

Factor reumatoideo, anticuerpos antipéptidos citrulinados y actividad de la enfermedad en pacientes con artritis reumatoidea Factor reumatoideo, anticuerpos antipéptidos citrulinados y actividad de la enfermedad en pacientes con artritis reumatoideaIntroducción: la artritis reumatoidea es una enfermedad inflamatoria crónica y multisistémica de causa autoinmune.Los anticuerpos antipéptidos citrulinados constituyen una herramienta importante para el diagnóstico de esta enfermedad. Objetivo: determinar la relación de los anticuerpos factor reumatoideo y antipéptidos citrulinados de segunda y tercera  generación, con indicadores clínicos y serológicos de actividad de la enfermedad en pacientes con artritis reumatoidea establecida. Material y métodos: participaron 88 pacientes con artritis reumatoidea establecida y se determinaron la proteína C reactiva, la velocidad de sedimentación globular, el índice de actividad de la enfermedad basado en el conteo de 28 articulaciones (DAS 28). Los autoanticuerpos factor reumatoideo y antipéptidos citrulinados de segunda y tercera generación se cuantificaron mediante el ensayo de inmunoabsorción ligado a enzimas. Resultados: se observó asociación entre la positividad de proteína C reactiva y la presencia de todos los autoanticuerpos. El factor reumatoideo y los anticuerpos antipéptidos citrulinados mostraron correlación positiva con la velocidad de sedimentación globular y con el DAS 28. Solamente los anticuerpos antipéptidos citrulinados se asociaron con una actividad moderada o alta de la enfermedad. Conclusiones: los anticuerpos antipéptidos citrulinados de segunda y tercera generación tienen gran valor para la identificación de pacientes con un curso más severo de la enfermedad en la artritis reumatoidea establecida.Palabras clave: artritis reumatoidea, autoanticuerpos, factor reumatoideo, antipéptidos citrulinados, enfermedad autoinmune, indicadores clínicos, indicadores serológicos.ABSTRACTIntroduction: rheumatoid arthritis is a chronic inflammatory disease, multisystem and with autoimmune cause. Antibodies anti- citrullinated peptides are an important tool for the diagnosis of this disease. Objective: to determine the relationship of rheumatoid factor, anti-mutated citrullinated vimentin and anti-citrullinated peptides of second and third generation antibodies, with clinical and serological indicators of disease activity in patients with established rheumatoid arthritis. Material and methods: 88 patients with established rheumatoid arthritis participated in the study and C reactive protein, erythrocyte sedimentation rate, disease activity score based on the count of 28 joints (DAS 28) and autoantibodies were measured.  Rheumatoid factor and anti-citrullinated peptides of second and third generation autoantibodies were quantified by enzyme-linked immunosorbent assay. Results: association between C reactive protein and the presence of all autoantibodies was observed. Rheumatoid factor and anti-citrullinated peptides antibodies of second and third generation showed positive correlation with ESR and DAS 28. Only anti-citrullinated peptide antibodies were associated with a moderate or high disease activity. Conclusions: anti-citrullinated peptide antibodies of second and third generation are of great value for identifying patients with more severe disease course in established rheumatoid arthritis.Keys words: rheumatoid arthritis, autoantibodies, rheumatoid factor, anti- citrullinated peptides, autoimmune disease, clinical indicators, serological indicators.

Objetivo: determinar la relación de los anticuerpos factor reumatoideo y antipéptidos citrulinados de segunda y tercera  generación, con indicadores clínicos y serológicos de actividad de la enfermedad en pacientes con artritis reumatoidea establecid... see more

According to the data of the International Union of Phlebologists venous pathologies in various forms occur in 60-75% of the population. InEurope, the lower limb varicosity is observed in 25-33% of women and 10-20% of men; it allows to reliably refer the ... see more

Introduction. The treatment of destructive inflammatory joint diseases (arthropathies) is one of the issues of current interest in modern medicine. In destructive inflammatory diseases, the regenerative ability of cartilaginous tissue proves to be inadequ... see more

58th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR), European Society for Neonatology (ESN), Union of European Neonatal & Perinatal Soci... see more

Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease with impact on increasing the morbidity and mortality rates. Different levels of disease activity (LDA) have been established, however, its impact on pain and quality of lif... see more

Osteoarthritis (OA) is a disease that is often found in all parts of the world. OA often affects women or men, especially those who are elderly. It’s not uncommon for people with OA to complain the intensity of pain due to the disease. OA is a degenerativ... see more

1 of 4.782 pages  |  10  records  |  more records»