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10.625  Articles
1 of 1.063 pages  |  10  records  |  more records»
The estrogen receptor alpha (ERa) plays an important role in breast development and pro-proliferation signal activation in the normal and cancerous breast. The ERa inhibitors were potentially active as cytotoxic agents against breast cancer. This study wa... see more

Employing ensemble Protein-Ligand Interaction Fingerprints (ensPLIF) as descriptors in post retrospective Structure-Based Virtual Screening (SBVS) campaigns Quantitative Structure-Activity Relationship (QSAR) analysis has been proven to significantly incr... see more

A cyclooxygenase-2 (COX-2) inhibitor celecoxib has been previously reported to have cytotoxic activities towards gastric, prostate, ovarian, colon and breast cancer cell lines. This article reports that the cytotoxic activities of celecoxib could be resul... see more

The publicly available enhanced data of ligands and decoys for estrogen receptor alpha (ERa) which were recently published has made the retrospective validation of a structure-based virtual screening (SBVS) protocol to identify ligands for ERa possible. I... see more

BACKGROUND: The current consensus on idiopathic scoliosis maintains that it has a multifactorial etiology with genetic predisposing factors.AIM: Estrogen receptor alpha gene has been considered as candidate gene of idiopathic scoliosis.MATERIAL AND METHOD... see more

Breast cancer is an uncontrolled malignancy of the breast that originates from glandular cells, gland ducts, and the supporting tissues of the breast. The development of herbal-based anticancer drugs is progressing, one of which is derived from the natura... see more

Breast cancer is an uncontrolled malignancy of the breast that originates from glandular cells, gland ducts, and the supporting tissues of the breast. The development of herbal-based anticancer drugs is progressing, one of which is derived from the natura... see more

Breast cancer is the highest mortality cause in women with cancer. Protein-protein docking for target-based screening is an effective approach in breast cancer drug discovery via estrogen receptor (ER) signaling. TRIM56, an E3 ubiquitin protein ligase, ca... see more

Breast cancer is the highest mortality cause in women with cancer. Protein-protein docking for target-based screening is an effective approach in breast cancer drug discovery via estrogen receptor (ER) signaling. TRIM56, an E3 ubiquitin protein ligase, ca... see more

1 of 1.063 pages  |  10  records  |  more records»