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25.997  Articles
1 of 2.601 pages  |  10  records  |  more records»
Mitochondria, cytoplasmic organelles originated from endosymbiotic bacteria, can be metaphorically described using “Janus bifrons” image, due to their involvement in life, providing cellular energy and resulting essential even for stem cells, but playing ... see more

Metabolomics has provided new insight into the biology that drives the phenotype of stem cells. During the recent years, metabolic circuits of embryonic and neural stem cells (NSCs) have been better elucidated. Many factors contribute to stem cell determi... see more

Early pancreas development, given its complexity, is generally considered as a paradigm for branching morphogenesis and for the development of two organs in one: the Langherans islets, programmed to secrete hormones into the bloodstream, and the exocrine ... see more

Premature birth is a major public health issue internationally affecting 13 million babies worldwide. Hypoxia and ischemia is probably the commonest type of acquired brain damage in preterm infants. The clinical manifestations of hypoxic-ischemic injury i... see more

Periventricular leucomalacia (PVL) is traditionally considered a multifactorial lesion related to three main mechanisms: ischemia, inflammation and excitotoxicity. For years it was believed that hypoperfusion, associated with the peculiar vascular anatomy... see more

Bronchopulmonary dysplasia (BPD) is a chronic lung disease occurring in preterm infants, typically before 28 weeks of gestational age, characterized by a prolonged need for supplemental oxygen or positive pressure ventilation. The normal stages of lung de... see more

In this paper, the main epigenetic factors involved in shaping the brain’s physical structure during development will be reviewed, with special emphasis on those related to Parkinson’s disease and Alzheimer’s disease in adulthood. These factors are: prete... see more

Human Milk Oligosaccharides (HMOs), the third most important solid components of BM (the first and the second being lactose and lipids respectively), are a highly variable family of unconjugated glycans related to many pathophysiological short- and long-t... see more

The development of the central nervous system represents a very delicate period of embryogenesis. Premature interruption of neurogenesis in human preterm newborns can lead to motor deficits, including cerebral palsy, and significant cognitive, behavioral ... see more

1 of 2.601 pages  |  10  records  |  more records»