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141.371  Articles
1 of 14.138 pages  |  10  records  |  more records»
IntroductionLiver fibrosis (LF) results from the unregulated chronic wound healing process in liver tissue. Transforming growth factor-beta (TGF-ß) is the major contributing cytokine of LF promotion through activation of quiescent hepatic stellate cells (... see more

Metastasis of tumor cells from primary sites of malignancy to neighboring stromal tissue or distant localities entails in several instances, but not in every case, the epithelial-mesenchymal transition (EMT). EMT weakens the strong adhesion forces between... see more

Background: In recent decades platyhelminths have been used as model organisms to address some of the fundamental questions related to the growth and development of animal organisms. Epidermal Growth Factor Receptors (EGFR) and Transforming Growth Factor ... see more

The antifibrotic potential of platelet-rich plasma (PRP) is controversial. This study examined the effects of PRP on in vitro transforming growth factor (TGF)-β1-induced differentiation of fibroblasts into myofibroblasts, the main drivers of fibrosis... see more

It is well recognized that cancer cells subvert the phenotype of stromal naïve fibroblasts and instruct the neighboring cells to sustain their growth agenda. The mechanisms underpinning the switch of fibroblasts to cancer-associated fibroblasts (CAFs) are... see more

The transforming growth factor-ß (TGF-ß) pathway has a tumor suppressor role in normal and premalignant cells but promotes oncogenesis in advanced cancer cells. Components of the pathway are tightly controlled by ubiquitin modifying enzymes and aberration... see more

One of the proinflammatory agents in the human body is lead (Pb), which can enter the blood through the skin, respiratory tract and digestive tract, causing poisoning. Its most significant target is the central nervous system (CNS). Although studies on&nb... see more

Background: Orthodontic tooth movement occurred as a result of alveolar bone remodeling and collagen due to mechanical load. This mechanical load applied to the tooth will exert a number of cytokine and growth factors. One of the growth factors that are o... see more

Cardiovascular diseases are the disorder of artery carrying blood into heart muscle and characterized by thickening, stiffening and constriction of the artery. In spite of cardiovascular disease cases have been knownsince along time ago, the main factor, ... see more

1 of 14.138 pages  |  10  records  |  more records»