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2.100  Articles
1 of 210 pages  |  10  records  |  more records»
Cancer is a main public health problem all over the world. It affects millions of humans no matter their age, gender, education, or social status. Although chemotherapy is the main strategy for the treatment of cancer, a major problem limiting its success... see more

Calcium is one of the most important second messengers and its intracellular signaling regulates many aspects of cell physiology. Calcium ions, like phosphate ions, are highly charged and thus are able to alter protein conformation upon binding; thereby t... see more

Background. The article provides a brief overview of the main publications on networked medicine and the application of an integrated network analysis of protein interactions in the study of human diseases. Given the functional interdependencies between t... see more

Silver nanoparticles (AgNPs), an emerging environmental contaminant, have been developed as antimicrobials, biosensors, and for other applications in products ranging from medical devices to consumer goods including toothpaste, socks, and appliances. AgNP... see more

Background. The article provides a brief overview of the main publications on networked medicine and the application of an integrated network analysis of protein interactions in the study of human diseases. Given the functional interdependencies between t... see more

Objective High-intensity exercise, which increases blood lactate concentration, is known as an effective method to induce mitochondrial biogenesis compared to traditional endurance exercise. In addition, it has been reported that lactate acts as a signali... see more

Type 2 diabetes (T2D), which is an epidemic of the 20th century, increases mortality, caused not only by cardiovascular diseases but also cancer. Pathogenetic factors of T2D lead to dysfunction of intracellular regulatory systems, particularly of PI3K/Akt... see more

We investigated toxicological effects of two of the most common polybrominated diphenyl ether (PBDE) flame retardants, BDE-47 and BDE-209, in model PC12 cell line under two environmentally relevant exposure conditions:  long term exposure to microgra... see more

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