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16.406  Articles
1 of 1.642 pages  |  10  records  |  more records»
Nowadays, the innovative direction of pharmaceutical development is the application of methods to increase the biopharmaceutical efficiency and safety of the use of already existing APIs, including method of incorporating them into solid dispersions in wh... see more

Nowadays, the innovative direction of pharmaceutical development is the application of methods to increase the biopharmaceutical efficiency and safety of the use of already existing APIs, including method of incorporating them into solid dispersions in wh... see more

The solid dispersions of indomethacin with hydrophilic polymers were prepared by lyophilization. The polymers used in the investigation were HPMC, PVP K30, CBR and PLF 127. The solubility and dissolution of indomethacin from prepared lyophilized solid dis... see more

Investigation on in vitro and in vivo behavior of solid dispersions containing Tolvaptan is the focus of the present research work. The effect of various hydrophilic polymers on the aqueous solubility was studied. Kleptose HPB was selected as carrier... see more

Metronidazole is a broad spectrum antibiotic. It is sparingly soluble in water but has oral bioavailability of 93-95%. So solid dispersions (SDs) containing metronidazole was prepared in different ratios (1:1, 1:2 and 1:5) and using different carriers lik... see more

The objective of the present investigation is focused on the preparation of solid dispersions containing Nevirapine. The effect of various hydrophilic polymers on the aqueous solubility was studied. Kolliphor P188 was selected as carrier and solid dispers... see more

The objective of this study was to develop solid dispersions of Nifedipine which has low aqueous solubility and bioavailability. Preliminary solubility studies were carried out using various hydrophilic polymers. The formulations were then optimized and e... see more

The basic objectives of this study were to prepare and characterize solid dispersions of poorly water-soluble drug fluconazole using hydrophilic carriers by spray drying technique. In the present study, a spray drying technique has been used to prepare so... see more

Several technical factors related to penicillin G intramuscular injection can affect its bioavailability and hence reduce the efficacy of rheumatic fever prevention program. When small amount of diluent is used, the powder is not completely dissolved and ... see more

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