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The PGC1 family (Peroxisome proliferator-activated receptor ? (PPAR?) coactivators) of transcriptional coactivators are considered master regulators of mitochondrial biogenesis and function. The PGC1a isoform is expressed especially in metabolically activ... see more

Objective To observe the effect of treadmill exercise on brown adipose tissue of heart failure rats induced by abdominal aortic constriction(AAC). Methods 210g healthy male SD rats were randomly divided into control group and AAC group,after 4 w... see more

Objective To investigate the molecular mechanism of AMPK-mediated motion reduction of Aß deposition in the hippocampus of APP/PS1 mice.Methods The 3 months of C57BL/6 48 APP/PS1 mice and 48 wildtype mice were randomly divided into APP/PS1 quiet control gr... see more

Objective To study the effect of different time of electrical stimulation on C2C12 myotubes function, and further explore its molecular mechanism.Methods An electrical stimulation was given 7 days after C2C12 myotubes differentiation, of which intensity w... see more

Objective Exercise can induce the release of various myokine such as Irisin, which promote browning of white fat, improve body metabolism, and loss weight. Appropriate hypoxic training plays a better role in weight loss than single exercise, but the effec... see more

Background: Obesity has currently become a serious social problem to be solved. Sesamol, a natural bioactive substance extracted from sesame oil, has shown multiple physiological functions, and it might have an effect on the treatment of obesity.Objective... see more

Skeletal muscle has a major role in locomotion and muscle disorders are associated with poor regenerative efficiency. Therefore, a deeper understanding of muscle regeneration is needed to provide a new insight for new therapies. CaMKK2 plays a role in the... see more

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