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72.861  Articles
1 of 7.287 pages  |  10  records  |  more records»
In addition to their canonical function as negative regulators of G protein coupled receptors (GPCRs), arrestins, a small family of cyclic protein, serve as multi-functional adaptors by tethering several signaling components together. To elicit the approp... see more

"Signal specificity is achieved through highly-regulated molecular recognition. Arrestins, a small family of multi-functional adaptor proteins, mediate surprisingly complex cellular signaling events. To elicit the appropriate cellular response, arrestins ... see more

Unfavorable ecological and food security situation in the world causes frequent spread of diseases of the gastrointestinal tract. In particular, the number of cases of irritable bowel syndrome is increasing, especially among the young working population. ... see more

The present study aims at numerically describing to what extent substrate - enzyme complexes in solution may change over time as a natural process of conformational changes for a liganded enzyme in comparison to those movements which occur independently f... see more

Specific interactions between scaffold protein SH3 and multiple ankyrin repeat domains protein 3 (Shank3) and synapse-associated protein 90/postsynaptic density-95–associated protein (SAPAP) are essential for excitatory synapse development and plast... see more

Small molecules, such as solvent, substrate, and cofactor molecules, are key players in enzyme catalysis. Computational methods are powerful tools for exploring the dynamics and thermodynamics of these small molecules as they participate in or contribute ... see more

Diabetes mellitus is a chronic disease responsible for one of the world's most common publichealth problems. Its prevalence, comorbidities, and medical costs assume a dramatic scale andan efficient response to these projections is the intensified ... see more

The early signs of vibration effects on the human body are microcirculation and transcapillary metabolism disorders, accompanied by disruption of the supply to and utilization of oxygen in the tissues and organs. However, there are few experimental studie... see more

Sickle cell disease (SCD) is a molecular disease caused by substituting glutamic acid with valine at the ß-6 position of the hemoglobin, leading to the polymerization of erythrocytes that contain the hemoglobin afterward leads to severe clinical consequen... see more

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