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59.918  Articles
1 of 5.993 pages  |  10  records  |  more records»
In recent years, the use of Bisphenol A (BPA) has been regulated in many countries because of its potential adverse effects on human health. As a result of the restriction, structural analogues such as bisphenol F (BPF) have already been used for industri... see more

Lysosomal storage diseases (LSDs) are a group of more than 50 genetic disorders.  Clinical symptoms are caused by the deficiency of specific enzyme (enzymes) function and resultant substrate accumulation in the lysosomes, which leads to impaired cell... see more

Lysosomal storage diseases (LSDs) are a group of more than 50 genetic disorders.  Clinical symptoms are caused by the deficiency of specific enzyme (enzymes) function and resultant substrate accumulation in the lysosomes, which leads to impaired cell... see more

Objective Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by aggregation of amyloid-ß (Aß) peptides. Reduction of progressive accumulation of Aß will delay the progression of AD. As a main digestive organelles in cells, l... see more

Metabolic phenotyping is poised as a powerful and promising tool for biomarker discovery in inherited metabolic diseases. However, few studies applied this approach to mcopolysaccharidoses (MPS). Thus, this innovative functional approach may unveil compre... see more

Introduction. In the pathogenesis of many pathological conditions, the violation of the proteinase-inhibitor system is important. In the absence of proper control of proteolysis, a number of pathological conditions, accompanied by the appearance of destru... see more

Introduction. In the pathogenesis of many pathological conditions, the violation of the proteinase-inhibitor system is important. In the absence of proper control of proteolysis, a number of pathological conditions, accompanied by the appearance of destru... see more

Fabry disease (FD) is a relatively rare X-linked hereditary disease caused by mutations in the GLA gene that results in deficient a-galactosidase A (a-Gal A) enzyme activity. The disturbed catabolism of the neutral sphingolipids globotriaosylceramide (Gb3... see more

 Background: Osteoporosis, that denotes the bone porosity, is the disease, when the bone mineral density (BMD) is decreased. Bones become porous and fragile, that increase the risk of bone fractures. Bone mass loss develops slowly and progressively. ... see more

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