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In the present review, we briefly discuss the breakthrough advances in precision medicine using a tumor-agnostic approach and focus on BRAF treatment modalities, the mechanisms of resistance and the diagnostic approach in cancers with BRAF mutations. Tumo... see more

Introdução: A proteína BRAF pertence a família RAF de quinases da serina/treonina, e a via RAS/RAF/MEK/ERK atua como transdutora de sinal entre o meio extracelular e núcleo. Sinais extracelulares interagem com os seus receptores e ativam membros da famíli... see more

Mutations in the KRAS (Kirsten rat sarcoma viral oncogene homolog gene) and BRAF (v-Raf murine sarcoma viral oncogene homolog B1) gene play a significant role in primary resistance to colorectal cancer therapy. Around 85-90% of KRAS mutations in colorecta... see more

Paper description: Papillary thyroid carcinoma (PTC), usually curable, sometimes progresses to aggressive forms. Analysis of molecular alterations is helpful in predicting disease course and therapy decisions. BRAF gene mutations and epidermal growth fact... see more

Ovarian neoplasms are group of aggressive and lethal diseases.  Surgical and radiochemical therapies on ovarian neoplasm are conventional approaches but with limited progress in years.  Targeted therapy with drugs targeting specific genetic alte... see more

Adenokarsinoma kolorektal adalah tumor ganas epitel kolorektal yang berdiferensiasi kelenjar. Metastasis ke kelenjar getah bening sangat memengaruhi prognosis dan penatalaksanaan penderita karsinoma kolorektal. Penelitian ini untuk mengetahui hubungan BRA... see more

Karsinoma kolorektal (KKR) didefinisikan sebagai suatu tumor ganas epitelial usus besar yang terjadi akibat pengaruh dari faktor ekstrinsik dan intrinsik. BRAF adalah salah satu serine/theonine protein kinase yang berperan dalam kaskade sinyal yang mengat... see more


Los estudios de melanoma en Guatemala han sido pocos y únicamente se ha evaluado el aspecto clínico e histológico. El objetivo del presente estudio fue determinar la proporción de casos de melanoma cutáneo por morfología, inmunohistoquímica y mutación del... see more

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