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3.890  Articles
1 of 389 pages  |  10  records  |  more records»
Curcumin, a polyphenolic compound, derived from the rhizomes of Curcuma longa L. Curcumin shows potential pharmacological action against numerous disorders, including cancer, neurodegenerative, and infection diseases. Curcumin-based molecular imaging agen... see more

Alzheimer’s disease (AD) belongs to the class of neurodegenerative disorder and is biochemically characterized by amyloid-ß (Aß) plaques deposition, accumulation of neurofibrillary tangles (NFTs) accumulation and ultimately neuronal loss. Even though, the... see more

 
Alzheimer’s disease (AD) is a brain disease attributed to the accumulation of extracellular senile plaques comprising ß-amyloid peptide (Aß). In this study, a transgenic Caenorhabditis elegans (C. elegans) containing the human beta amyloid Aß42 gene which... see more

Acteoside and isoacteoside, two phenylethanoid glycosides, coexist in some plants. This study investigates the memory-improving and cytoprotective effects of acteoside and isoacteoside in amyloid ß peptide 1-42 (Aß 1-42)-infused rats and Aß 1-42-treated S... see more

Alzheimer’s disease (AD) is characterized by extracellular plaques in the brain, mainly consisting of amyloid-ß (Aß), as derived from sequential cleavage of the amyloid precursor protein. Epidemiological studies suggest a tight link between hypovitaminosi... see more

Protein aggregation into highly ordered supramolecular aggregates is the hallmark of many degenerative diseases including the neurological disorders (Parkinson’s, Alzheimer’s, and Huntington’s diseases), type II diabetes, systemic amyloidosis, spongiform ... see more

Sporadic dementia of Alzheimer’s type (SDAT) pathogenesis has not been revealed completely due to the difficulty in creating an appropriate animal model. The purpose of this study was to investigate the effect of single-dose intraperitoneal (IP) induction... see more

The binding of the benzanthrone dye ABM to the model amyloid fibrils of human insulin, referred to here as vealyl (12-VEALYL-17, insulin B-chain)), lyqlen (13-LYQLEN-18, insulin A-chain) and Insf ( 11-LVEALYL-17, B-chain) + 12-SLYQLENY-19, A-chain) was st... see more

The three-step Förster resonance energy transfer (FRET) within the cascade of four dyes, including the classical amyloid marker Thioflavin T as a primary donor, two jumper dyes, benzanthrone ABM and squaraine SQ4, and terminal acceptor SQ1, was tested as ... see more

1 of 389 pages  |  10  records  |  more records»